110333-20-5

Basic information

• Product Name: {5-oxo-4-[2-oxo-2-(prop-2-en-1-yloxy)ethyl]-1,3-dioxolan-4-yl}acetic acid
• CAS NO: 110333-20-5
• Molecular Formula: C₁₀H₁₂O₇
• Molecular Weight: 244.1981
• Mol File: 110333-20-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 436.6°C at 760 mmHg
• Flash Point: 172.7°C
• Density: 1.33g/cm³
• Vapor Pressure: 7.61E-09mmHg at 25°C
• Refractive Index: 1.485
• CAS DataBase Reference: {5-oxo-4-[2-oxo-2-(prop-2-en-1-yloxy)ethyl]-1,3-dioxolan-4-yl}acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {5-oxo-4-[2-oxo-2-(prop-2-en-1-yloxy)ethyl]-1,3-dioxolan-4-yl}acetic acid(110333-20-5)
• EPA Substance Registry System: {5-oxo-4-[2-oxo-2-(prop-2-en-1-yloxy)ethyl]-1,3-dioxolan-4-yl}acetic acid(110333-20-5)

Safety Data

• Hazardous Substances Data: 110333-20-5(Hazardous Substances Data)

Upstream product

• 77-92-9 citric acid 
• 144-16-1 5-oxo-1,3-dioxolan-4-ylidenedi(acetic acid) 
• 4767-12-8 4,4-(5-oxo-1,3-dioxolane)diacetic acid anhydride 
• 107-18-6 allyl alcohol 

Relevant articles and documents

The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase

We describe the synthesis of a variety of lipophilic isosteres of nucleoside triphosphates as potential anti-HIV agents. The citrate molecule proved to be a good mimic of triphosphate by modelling in terms of charge and spatial distribution. Several lipophile derivatives of citrate were conjugated to the precedented anti-HIV nucleoside d4T via ester and amide linkages. A novel synthesis of 5'-amino-d4T is included. Intramolecular rearrangement of several amide-linked isosteres are also reported, along with an alternative synthetic strategy to the desired amide-linked isosteres.