11034-45-0

Usage

InChI:InChI=1/C29H36O7/c1-16-19(30)15-29(35)25(33)23-17(2)20(36-21(31)12-11-18-9-7-6-8-10-18)13-14-28(23,5)26(34)24(32)22(16)27(29,3)4/h6-12,20,23-26,32-35H,2,13-15H2,1,3-5H3/b12-11-/t20-,23?,24+,25-,26?,28?,29?/m0/s1

Upstream product

• 13452-36-3 2,9,10-triacetyl-5-O-cinnamoyltaxicin-I 
• 148090-72-6 2α,9α,10β-triacetyl-5α-cinnamoyltaxicine I 

Downstream Products

• 139126-20-8 C₃₅H₄₄O₇ 
• 139126-33-3 C₃₅H₄₆O₈ 
• 185942-10-3 C₃₈H₄₂O₇ 
• 273926-46-8 C₃₁H₃₂O₉ 
• 125544-21-0 2α,9α,10β-triacetoxy-1-hydroxy-5α-(3-phenyl-propionyloxy)-taxa-4(20),11-dien-13-one 
• 266676-47-5 C₆₆H₆₉NO₁₇ 
• 266676-48-6 C₅₉H₆₃NO₁₇ 
• 266676-52-2 C₄₅H₅₅N₅O₁₆ 

Relevant academic research and scientific papers

The synthesis and biological activity of 9- and 2'-cAMP 7- deoxypaclitaxel analogues from 5-cinnamoyltriacetyltaxicin-I

The synthesis and biological activity of new 7-deoxypaclitaxel analogues 3 and 4 in which the hydroxy group at C-2' of the side-chain, C-9 and C-10 in the B-ring are substituted by cAMP and benozoyloxy group respectively are presented. These derivatives have been first synthesized from a natural taxoid 5-cinnamoyltriacetyltaxicin-15 and tested in vitro for cytotoxicity against three human tumor cell lines. The biologically tested results indicate 3 having more potent cytotoxicity and 4 having a remarkably reduced cytotoxicity as well as 33 having no much effect on cytotoxicity against all human tumor cell lines tested in comparison to that of paclitaxel. (C) 2000 Elsevier Science Ltd.

Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue

Novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogues 17 and 22-24 synthesized from a natural taxoid 5-cinnamoyltriacetyltaxicin-I (3) and their biological evaluation in tubulin assembly activity and cytotoxicity in vitro against several human tumor cell lines are first presented. The biologically tested results show that 17, 22 and 23 are inactive in tubulin assembly assay and have no more remarkable cytotoxicities against human tumor cell lines SK-0V3, WIDR and MCF-7, though 22 and 23 exhibit more potent cytotoxicity against human liver cancer and human esophagus cancer cell lines (BEL-7402 and ECa-109) than paclitaxel. (C) 2000 Elsevier Science Ltd. All rights reserved.

Premiere Hemisynthese d'un Compose de Type Taxane Porteur d'un Groupement Oxetane en 4(20),5.

Key Words: Taxane hemisynthesis - Oxetane - Taxine B - Stereoselective reductionThe 1,2,9,10-diO-isopropylidene derivative of 2,4,9,10,13-pentadeacetyl-7-deacetoxybaccatin IV has been prepared in nine steps from taxine B, previously transformed in 2α,9α,1