1103501-79-6Relevant academic research and scientific papers
Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies
Nemoto, Toru,Yamamoto, Naoshi,Watanabe, Akio,Fujii, Hideaki,Hasebe, Ko,Nakajima, Mayumi,Mochizuki, Hidenori,Nagase, Hiroshi
, p. 1205 - 1221 (2011/04/12)
A novel 6,14-epoxymorphinan benzamide derivative (NS22) that was previously reported showed opioid κ receptor agonistic activity and analgesic activity. The unsatisfactory κ selectivity of NS22 led us to synthesize its derivatives to improve the opioid κ
Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology
Nemoto, Toru,Fujii, Hideaki,Narita, Minoru,Miyoshi, Kan,Nakamura, Atsushi,Suzuki, Tsutomu,Nagase, Hiroshi
scheme or table, p. 6398 - 6401 (2009/10/01)
A novel 6,14-epoxymorphinan benzamide derivative (NS22) was synthesized, which showed opioid κ receptor agonistic activity in the [35S]GTPγS binding assay. The antinociceptive effect of NS22 was evaluated in the tail-flick and the hot-plate test. This compound showed a potent antinociceptive activity in mice by sc administration, which was attenuated with nor-BNI (selective opioid κ receptor antagonist).
