110351-91-2 Usage
Molecular Weight
285.28 g/mol The mass of one mole of the compound, calculated from its molecular formula.
Structure
1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy-, (R)The specific arrangement of atoms and bonds in the compound, which determines its chemical and physical properties.
Trione Functional Group
A carbonyl group (C=O) that is part of a six-membered ring with two additional carbonyl groups. The presence of this functional group gives the compound its characteristic properties and reactivity.
Hydroxyl Group
A hydroxyl group (-OH) attached to a carbon atom. The presence of this group can affect the compound's solubility and reactivity.
Ethyl Substituent
An ethyl group (-CH2-CH3) attached to the 4th carbon atom of the molecule. The presence of this substituent can affect the compound's physical and chemical properties.
R Enantiomer
One of two mirror-image forms of the compound that cannot be superimposed on each other. The R enantiomer is the form that is being described in the material provided.
Pharmacological and Therapeutic Properties
The potential for the compound to be used as a drug for the treatment of diseases or medical conditions. This property makes the compound of interest for further research and development in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 110351-91-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,3,5 and 1 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 110351-91:
(8*1)+(7*1)+(6*0)+(5*3)+(4*5)+(3*1)+(2*9)+(1*1)=72
72 % 10 = 2
So 110351-91-2 is a valid CAS Registry Number.
110351-91-2Relevant academic research and scientific papers
Synthetic studies on camptothecins. Part 3
Kuang, Yun-Yan,Niu, Jing-Ze,Chen, Fen-Er
experimental part, p. 2094 - 2099 (2010/12/25)
A concise and efficient asymmetric process for the total synthesis of (20S)-7-ethyl-10-hydroxycamptothecin (=SN-38; 1f), an active metabolic form of the prodrug irinotecan, is described. This approach features the enantioselective cyanosilylation of indolizinone 4 into the corresponding cyanohydrin 5, mediated by a bifunctional thiourea-based cinchona alkaloid under mild conditions, and I2-catalyzed Friedlnder condensation of the tricyclic lactone 6 and 2-amino-5-hydroxy propiophenone (=1-(2-amino-5- hydroxyphenyl)propan-1-one). Copyright
