1103585-01-8

Usage

Uses

Used in Pharmaceutical Research:
(E)-3-(3,4,5-trimethoxyphenyl)-1-(4-nitrophenyl)prop-2-en-1-one is used as a compound of interest in pharmaceutical research for its potential anti-inflammatory, antioxidant, and antimicrobial properties. These characteristics make it a promising candidate for the development of new drugs targeting a range of conditions and diseases.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (E)-3-(3,4,5-trimethoxyphenyl)-1-(4-nitrophenyl)prop-2-en-1-one is utilized as a starting material or a structural component in the synthesis of novel therapeutic agents. Its unique arrangement of functional groups can be exploited to design and create new molecules with enhanced biological activities and improved pharmacological profiles.
Used in Drug Development:
(E)-3-(3,4,5-trimethoxyphenyl)-1-(4-nitrophenyl)prop-2-en-1-one is also used in drug development as a potential lead compound. Its structure can be further optimized and modified to enhance its therapeutic potential, targeting specific diseases or conditions with higher efficacy and selectivity.
Used in Antimicrobial Applications:
Given its potential antimicrobial properties, (E)-3-(3,4,5-trimethoxyphenyl)-1-(4-nitrophenyl)prop-2-en-1-one can be used as an antimicrobial agent in the development of new antibiotics or antifungal medications, addressing the growing need for novel treatments against drug-resistant infections.
Used in Antioxidant Formulations:
As a compound with potential antioxidant activity, (E)-3-(3,4,5-trimethoxyphenyl)-1-(4-nitrophenyl)prop-2-en-1-one can be incorporated into antioxidant formulations for use in the healthcare and cosmetics industries, where such properties are highly valued for their ability to protect cells from oxidative damage and promote overall health and well-being.

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 1037642-78-6 (E)-1-(4-aminophenyl)-3-(3,4,5-trimethoxyphenyl)-prop-2-en-1-one 

Relevant academic research and scientific papers

Synthesis and biological activity of new chalcone scaffolds as prospective antimicrobial agents

Chalcones are open-chain flavonoids which contains two aromatic rings are joined by 3-carbons α-, β-unsaturated carbonyl chain. The, β-unsaturated ketonic group which is liable for the antimicrobial activity of the chalcone is additionally of vast use in

A novel series of benzothiazepine derivatives as tubulin polymerization inhibitors with anti-tumor potency

In this work, a series of diaryl benzo[b][1,4]thiazepine derivatives D1-D36 were synthesized and screened as tubulin polymerization inhibitors with anti-tumor potency. They were designed by introducing the seven-member ring benzothiazepine as the linker f

Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling

Ras proteins are small GTPases which regulate cellular proliferation, differentiation, and apoptosis. Constitutively active mutant Ras are expressed in ~15–20% human cancers, and K-Ras mutations account for ~85% of all Ras mutations. Despite the significa

Hybrid α-bromoacryloylamido chalcones. Design, synthesis and biological evaluation

Research into the anti-tumor properties of chalcones has received significant attention over the last few years Two novel large series of α-bromoacryloylamido chalcones 1a-m and 2a-k containing a pair of Michael acceptors in their structures, corresponding to the α-bromoacryloyl moiety and the α,β-unsaturated ketone system of the chalcone framework, were synthesized and evaluated for antiproliferative activity against five cancer cell lines. Such hybrid derivatives demonstrated significantly increased anti-tumor activity compared with the corresponding amino chalcones. The most promising lead molecules were 1k, 1m and 2j, which had the highest activity toward the five cell lines. Flow cytometry with K562 cells showed that the most active compounds resulted in a large proportion of the cells entering in the apoptotic sub-G0-G1 peak. Moreover, compound 1k induced apoptosis through the mitochondrial pathway and activated caspase-3.