11037-01-7

Basic information

• Product Name: 20-ethyl-4-(hydroxymethyl)-1,16-dimethoxyaconitane-8,14-diol
• CAS NO: 11037-01-7
• Molecular Formula: C₂₃H₃₇NO₅
• Molecular Weight: 407.5436
• Mol File: 11037-01-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 540.5°C at 760 mmHg
• Flash Point: 280.7°C
• Density: 1.31g/cm³
• Vapor Pressure: 6.15E-14mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 20-ethyl-4-(hydroxymethyl)-1,16-dimethoxyaconitane-8,14-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 20-ethyl-4-(hydroxymethyl)-1,16-dimethoxyaconitane-8,14-diol(11037-01-7)
• EPA Substance Registry System: 20-ethyl-4-(hydroxymethyl)-1,16-dimethoxyaconitane-8,14-diol(11037-01-7)

Safety Data

• Hazardous Substances Data: 11037-01-7(Hazardous Substances Data)

Upstream product

• 58969-45-2 aconorine 

Downstream Products

• 38839-95-1 aconosine 

Relevant articles and documents

Isolation, Structure Elucidation, Semi-Synthesis, and Structural Modification of C19-Diterpenoid Alkaloids fromAconitum apetalumand Their Neuroprotective Activities

Five new aconitine-type C19-diterpenoid alkaloids, apetalrines A-E (1-5), were isolated fromAconitum apetalum. Their structures were determined by analysis of 1D and 2D NMR, IR, and HRESIMS data. Semisynthesis of apetalrine B (2) from its parent compound aconorine was achieved to confirm the structure proposed. Twenty derivatives of2(11a-11l12a12b12d12e12j12k12m12n) were synthesized via a unified approach relying on simple coupling reactions. The evaluation of neuroprotective effects of compounds (1-511b11c11f-11i12a12b12d12e12k12m12n) with low cytotoxicity revealed compound2to exhibit good neuroprotective effects in H2O2-treated SH-SY5Y cells at a concentration of 50 μM. A series of studies using flow cytometry, staining, and Western blotting on2indicated that its neuroprotective effects may arise from inhibiting cell apoptosis.