1103795-58-9Relevant articles and documents
SPIRO SUBSTITUTED CYCLOPROPANE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
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Page/Page column 19; 21, (2009/10/01)
A compound of the Formula I: or a pharmaceutically acceptable salt, solvate or isomer thereof, can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-alpha or combinations thereof.
Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors
Guo, Zhuyan,Orth, Peter,Wong, Shing-Chun,Lavey, Brian J.,Shih, Neng-Yang,Niu, Xiaoda,Lundell, Daniel J.,Madison, Vincent,Kozlowski, Joseph A.
scheme or table, p. 54 - 57 (2009/04/10)
We have discovered nanomolar inhibitors of TNF-α convertase (TACE) comprised of a novel spirocyclic scaffold and either a carboxylate or hydroxamate zinc binding moiety. X-ray crystal structures and computer models of selected compounds binding to TACE ex
