1103795-64-7Relevant academic research and scientific papers
Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors
Guo, Zhuyan,Orth, Peter,Wong, Shing-Chun,Lavey, Brian J.,Shih, Neng-Yang,Niu, Xiaoda,Lundell, Daniel J.,Madison, Vincent,Kozlowski, Joseph A.
scheme or table, p. 54 - 57 (2009/04/10)
We have discovered nanomolar inhibitors of TNF-α convertase (TACE) comprised of a novel spirocyclic scaffold and either a carboxylate or hydroxamate zinc binding moiety. X-ray crystal structures and computer models of selected compounds binding to TACE ex
