1103893-41-9

Upstream product

• 1103893-36-2 (2S,4S)-1-ethyl 2-methyl 4-(4-nitrobenzoyloxy)pyrrolidine-1,2-dicarboxylate 
• 330623-57-9 (2S,4S)-1-ethyl 2-methyl 4-hydroxypirrolidine-1,2-dicarboxylate 
• 172947-80-7 (2S,4R)-1-ethyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1103893-52-2 ((2S,4S)-2(hydroxydiphenylmethyl)-4-methoxypyrrolidin-1-yl)(pyridin-2-yl)methanone 

Relevant academic research and scientific papers

Highly enantioselective synthesis of β-amino acid derivatives by the lewis base catalyzed hydrosilylation of β-enamino esters

A study was conducted to demonstrate highly enantioselective synthesis of β-amino acid derivatives by the Lewis base catalyzed hydrosilylation of βenamino esters. It was found that these catalyst and its analogue displayed excellent activities and enantioselectivities in promoting hydrosilylation of N-aryl β-enamino esters. N-picolinoylpyrrolidine derivatives and N-picolioylephedrine were also evaluated in hydrosilylation of (Z)-methyl 3-phenyl-3-(phenylamino)acrylate. The generality of the Lewis base organocatalyzed hydrosilylation of various β-enamino esters were examined under the optimized conditions. It was observed that the catalytic system exhibited a high sensitivity to the N-substituents, while all the N-aryl β-enamino esters underwent the hydrosilylation smoothly to give corresponding β-amino esters.