1103917-23-2Relevant academic research and scientific papers
Formation of quaternary stereogenic centers by NHC-Cu-catalyzed asymmetric conjugate addition reactions with Grignard reagents on polyconjugated cyclic enones
Tissot, Matthieu,Poggiali, Daniele,Henon, Helene,Mueller, Daniel,Guenee, Laure,Mauduit, Marc,Alexakis, Alexandre
supporting information; experimental part, p. 8731 - 8747 (2012/09/25)
The copper-catalyzed conjugate addition of various Grignard reagents to polyconjugated enones (dienone and enynone derivatives) is reported. The catalyst system, composed of copper triflate and an NHC ligand, led to the unusual selective formation of the 1,4-addition products. This reaction allows for the creation of all-carbon chiral quaternary centers with enantiomeric excesses up to 99 %. The remaining unsaturation on the 1,4 adducts give access to valuable synthetic transformations. Copyright
