1104028-84-3

Upstream product

• 1104028-70-7 5-Chloro-N-[(1S *,2S *)-2-(3,5-difluorophenyl)-3,3,3-trifluoro-1-(hydroxymethyl)propyl]thiophene-2-sulfonamide 
• 1104029-29-9 N-(S)-(1-((S)-4-benzyl-2-oxooxazolidin-3-yl)-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-oxobutan-2-yl)-5-chloro-thiophene-2-sulfonamide 
• 1104077-79-3 N-((2S,3R)-1-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(3,5-difluorophenyl)-4,4,4-trifluoro-1-oxobutan-2-yl)-5-chlorothiophene-2-sulfonamide 
• 2766-74-7 5-chlorothien-2-ylsulfonyl chloride 
• 1104077-78-2 (2S,3R)-2-amino-3-(3,5-difluorophenyl)-4,4,4-trifluorobutan-1-ol hydrochloride 

Relevant academic research and scientific papers

INHIBITORS OF BETA AMYLOID PRODUCTION

Novel sulfonamide compounds useful in the treatment of conditions related to the production of beta-amyloid are described, as are routes to their preparation. The sulfonamide compounds are of the following structure, wherein R1-R3 are defined herein. Also provided are pharmaceutical compositions containing these compounds and/or prodrugs of these compounds and a physiologically compatible carrier. These compounds are specifically useful for inhibiting beta amyloid production, and treating Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome.

PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF HETEROCYCLIC SULFONAMIDE COMPOUNDS

Methods for preparing compound of formula (I) are described, wherein R1-R3 are defined herein, as are methods for preparing the intermediates formed therein. Also described are methods for enantioselectively preparing a chiral compou

Practical enantioselective synthesis of a 3-aryl-3-trifluoromethyl-2- aminopropanol derivative

Development of a large-scale enantioselective synthesis of a lead compound containing a 3-aryl-3-trifluoromethyl-2-aminopropanol core is described. A single isomer of 3,3-disubstituted acrylic acid derivative was prepared via Perkin condensation or Horner

PROCESS FOR THE PREPARATION OF TRIFLUOROALKYL-PHENYL AND HETEROCYCLIC SULFONAMIDES

A novel trifluoroacetylating agent, i.e., N-trifluoroacetylmorpholine, is described. This reagent is useful in the preparation of phenyl and heterocyclic sulfonamide compounds. Methods are therefore described for preparing sulfonamide compounds of the fol