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Gelsemiol, a toxic alkaloid found in plants of the Gelsemium genus, is a potent neurotoxin that can cause paralysis and respiratory failure in humans and animals when ingested. It acts as a competitive antagonist of the gamma-aminobutyric acid (GABA) receptor, leading to the inhibition of nerve impulses and muscle relaxation. Due to its extreme toxicity, gelsemiol has been historically used as a poison for criminal purposes, but it also has potential applications in medicine, particularly in the field of anesthesiology. However, its use is highly restricted and regulated.

110414-77-2

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110414-77-2 Usage

Uses

Used in Anesthesiology:
Gelsemiol is used as a potential anesthetic agent for its ability to induce muscle relaxation and inhibition of nerve impulses. Its potency and toxicity, however, require strict control and regulation in medical applications.
Used in Criminal Activities:
Historically, gelsemiol has been used as a poison for criminal purposes due to its highly toxic effects, causing paralysis and respiratory failure. However, it is important to note that the use of gelsemiol in such activities is illegal and unethical.

Check Digit Verification of cas no

The CAS Registry Mumber 110414-77-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,4,1 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 110414-77:
(8*1)+(7*1)+(6*0)+(5*4)+(4*1)+(3*4)+(2*7)+(1*7)=72
72 % 10 = 2
So 110414-77-2 is a valid CAS Registry Number.

110414-77-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cy clopenta[b]furan-2-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:110414-77-2 SDS

110414-77-2Downstream Products

110414-77-2Relevant academic research and scientific papers

Total synthesis of gelsemiol

Burch, Patrick,Binaghi, Massimo,Scherer, Manuel,Wentzel, Corinna,Bossert, David,Eberhardt, Luc,Neuburger, Markus,Scheiffele, Peter,Gademann, Karl

supporting information, p. 2589 - 2591 (2013/03/14)

Let it grow! The neuritogenic iridoid gelsemiol has been prepared in synthetic form by a radical cascade and skeletal rearrangement. This compound accelerates the differentiation of neurons and growth of neuritis (see scheme). Copyright

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