1104267-64-2Relevant academic research and scientific papers
A one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic α-amino acid derivatives activated by the combination of iodobenzene diacetate/iodine and iron dust
Fan, Renhua,Li, Weixun,Wang, Bing
experimental part, p. 4615 - 4621 (2009/03/12)
An efficient one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic α-amino acid derivatives with electron-rich aromatic compounds is reported. The reaction is activated by the combination of iodobenzene diacetate, iodine and iron dust, resulting in a mild and simple reaction system. The use of iron avoids the oxidation of aromatic compounds, and in situ generation of Fe(III) salts to promote the Friedel-Crafts reaction avoids the use of the highly hygroscopic FeCl3.
