1104461-35-9Relevant academic research and scientific papers
Phenyl isoxazole voltage-gated sodium channel blockers: Structure and activity relationship
Macsari, Istvan,Sandberg, Lars,Besidski, Yevgeni,Gravenfors, Ylva,Ginman, Tobias,Bylund, Johan,Bueters, Tjerk,Eriksson, Anders B.,Lund, Per-Eric,Venyike, Elisabet,Arvidsson, Per I.
scheme or table, p. 3871 - 3876 (2011/08/06)
Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective NaV1.7 blocker. Structural analogues of 1, both carbamates,
NEW COMPOUNDS 955
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Page/Page column 33-34, (2009/03/07)
Compounds of formula (I): wherein the substituents are as defined in the specification, are described and claimed. The invention further relates to pharmaceutical compositions containing said compounds and to the use of said compounds in therapy. The pres
