1104493-14-2Relevant academic research and scientific papers
Synthesis of [11C]PBR06 and [18F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO)
Wang, Min,Gao, Mingzhang,Miller, Kathy D.,Zheng, Qi-Huang
, p. 1331 - 1340 (2011/11/06)
The translocator protein 18 kDa (TSPO) is an attractive target for molecular imaging of neuroinflammation and tumor progression. [ 18F]PBR06, a fluorine-18 labeled form of PBR06, is a promising PET TSPO radioligand originally developed at NIMH.
Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET
Briard, Emmanuelle,Zoghbi, Sami S.,Siméon, Fabrice G.,Imaizumi, Masao,Gourley, Jonathan P.,Shetty, H. Umesha,Lu, Shuiyu,Fujita, Masahiro,Innis, Robert B.,Pike, Victor W.
experimental part, p. 688 - 699 (2009/12/28)
Elevated levels of peripheral benzodiazepine receptors (PBR) are associated with activated microglia in their response to inflammation. Hence, PBR imaging in vivo is valuable for investigating brain inflammatory conditions. Sensitive, easily prepared, and
