1104513-49-6

Basic information

• Product Name: tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate
• CAS NO: 1104513-49-6
• Molecular Weight: 296.797
• Mol File: 1104513-49-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate(1104513-49-6)
• EPA Substance Registry System: tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate(1104513-49-6)

Safety Data

• Hazardous Substances Data: 1104513-49-6(Hazardous Substances Data)

Upstream product

• 1193466-76-0 tert-butyl 4-chloropiperazine-1-carboxylate 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 615-41-8 2-iodochlorobenzene 

Downstream Products

• 41202-32-8 1-(2-chlorophenyl)piperazine hydrochloride 

Relevant articles and documents

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

Thiazolidine derivatives or salts thereof as an active ingredient an inhibitor Pim

PROBLEM TO BE SOLVED: To provide compounds which have excellent Pim inhibitory action and are useful as pharmaceuticals.SOLUTION: A compound is a thiazolidine derivative represented by the general formula (1) in the figure, or a salt thereof. (In the formula, X represents O or S; Rrepresents a hydrogen atom or a Calkyl group; Z, Z, Z, Z, Zand Zeach independently represent CH or N; Y represents an optionally substituted, divalent Caromatic hydrocarbon group or the like; Am represents a disubstituted amino group, or an optionally substituted, nitrogen-containing saturated heterocyclic group; and Rand Reach independently represent a hydrogen atom, a halogen atom, an alkyl group or the like.)

Synthesis of ortho -haloaminoarenes by aryne insertion of nitrogen-halide Bonds

A rapid and general access to ortho-haloaminoarenes has been developed by aryne insertion into N-chloramine, N-bromoamine, and N-iodoamine bonds via two complementary protocols harnessing fluoride-promoted 1,2-elimination of ortho-trimethylsilyl aryltriflates. Typically, electron-deficient N-chloramines effectively react with aryne intermediates generated at elevated temperature with CsF, while less stable N-haloamines are found more efficient under milder, TBAF-mediated aryne formation at room temperature. Both protocols demonstrate a good level of regioselectivity and functional group tolerance. Efforts to elucidate the mechanism of N-X insertion are also discussed. The practical value of this transformation is highlighted by rapid synthesis of novel analogues of the antipsychotic cariprazine.