A-Crystallin, also known as alpha-crystallin, is a lens protein that consists of two homologous subunits: αAand αB-crystallins. It exhibits chaperone-like activity and is crucial for maintaining lens transparency. A-Crystallin plays a significant role in preventing cataract formation and has been found to be affected by diabetic conditions.
Used in Pharmaceutical Industry:
A-Crystallin is used as a therapeutic target for the prevention and treatment of cataracts. Its chaperone-like activity helps maintain lens transparency and can be modulated by dietary antioxidants, such as curcumin, to prevent the loss of activity in diabetic conditions.
Used in Research Applications:
A-Crystallin is used as a model protein for studying the molecular chaperone function and its role in preventing protein aggregation. The understanding of its structure and function can provide insights into the development of therapeutic strategies for various diseases associated with protein misfolding and aggregation.
Used in Ophthalmology:
A-Crystallin is used as a biomarker for cataract development. Its decline in chaperone activity under diabetic conditions can be an indicator of the risk of cataract formation, and its modulation can be a potential therapeutic approach for cataract prevention and treatment.
Used in Pharmaceutical Industry:
A-Crystallin is used as a therapeutic target for the prevention and treatment of cataracts. Its chaperone-like activity helps maintain lens transparency and can be modulated by dietary antioxidants, such as curcumin, to prevent the loss of activity in diabetic conditions.
Used in Research Applications:
A-Crystallin is used as a model protein for studying the molecular chaperone function and its role in preventing protein aggregation. The understanding of its structure and function can provide insights into the development of therapeutic strategies for various diseases associated with protein misfolding and aggregation.
Used in Ophthalmology:
A-Crystallin is used as a biomarker for cataract development. Its decline in chaperone activity under diabetic conditions can be an indicator of the risk of cataract formation, and its modulation can be a potential therapeutic approach for cataract prevention and treatment.
11046-99-4
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Basic information
- Product Name: A-CRYSTALLIN
- Synonyms: A-CRYSTALLIN;bh-crystallin;bl-crystallin;hm-A-crystallin;CRYSTALLINS;B S-CRYSTALLIN;α-crystallin from bovine eye lens;βl-crystallin from bovine eye lens
- CAS NO:11046-99-4
- Molecular Formula: Unspecified
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Crystallin;Proteins and Derivatives;Structural Proteins
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: A-CRYSTALLIN(CAS DataBase Reference)
- NIST Chemistry Reference: A-CRYSTALLIN(11046-99-4)
- EPA Substance Registry System: A-CRYSTALLIN(11046-99-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 11046-99-4(Hazardous Substances Data)
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11046-99-4 Usage
Biochem/physiol Actions
α-Crystallin is a small heat-shock protein that has chaperone-like activity, preventing protein aggregation in vitro. Point mutations in α-crystallin genes are believed to be responsible for hereditary cataract development.Check Digit Verification of cas no
The CAS Registry Mumber 11046-99-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,4 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.Calculate Digit Verification of CAS Registry Number 11046-99:
(7*1)+(6*1)+(5*0)+(4*4)+(3*6)+(2*9)+(1*9)=74
74 % 10 = 4
So 11046-99-4 is a valid CAS Registry Number.
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A-CRYSTALLIN
