110464-44-3

Upstream product

• 43067-01-2 3,5-bis(methoxycarbonyl)-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine 

Downstream Products

• 128738-12-5 4-(2-Chloro-phenyl)-2-methyl-6-(pyridin-3-yloxymethyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 128738-07-8 2-(2-Amino-2-methoxycarbonyl-ethylsulfanylmethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 106852-98-6 2-(4-aminoethylthio)methyl-3,5-bis(methoxycarbonyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine 
• 100276-22-0 methyl 4-(2-chlorophenyl)-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3, 4-b]pyridine-3-carboxylate 
• 128738-11-4 4-(2-Chloro-phenyl)-2-(4-cyano-phenoxymethyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 128738-06-7 2-Benzylsulfanylmethyl-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 128738-14-7 2,6-Bis-benzylsulfanylmethyl-4-(2-chloro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 128738-08-9 4-(2-Chloro-phenyl)-2-methyl-6-(pyrimidin-2-ylsulfanylmethyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 128738-10-3 4-(2-Chloro-phenyl)-2-methyl-6-[1,2,4]triazol-1-ylmethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 128738-09-0 4-(2-Chloro-phenyl)-2-imidazol-1-ylmethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Long-acting Dihydropyridine Calcium Antagonists. Part 8. A Comparison of the Pharmacological and Pharmocokinetic Properties of Amlodipine with its Carba and Thio-bioisoesters

In order to evaluate the contribution to the overall pharmacokinetic and pharmacological profile of amlodipine made by the side-chain ether oxygen atom and the intramolecular hydrogen bond to the DHP ring NH proton, the profile of amlodipine was compared

FORMATION, SYNTHETIC UTILITY AND STRUCTURE ELUCIDATION OF A 2-BROMOMETHYL 1,4-DIHYDROPYRIDINE

The structure of the product obtained by reacting the 1,4-dihydropyridine 6 with pyridinium perbromide has been confirmed by NMR spectroscopy as the 2-bromomethyl derivative 7 and its reaction with a range of nucleophiles has been studied