110466-49-4

Upstream product

• 128260-16-2 2-hydroxy-3,3-dimethyl-5-phenyl-3,4-dihydro-2H-pyrrole 
• 119220-05-2 3-benzoyl-3-methyl-1-phenylpentane-1,4-dione 
• 70-11-1 α-bromoacetophenone 
• 128259-94-9 3,3-dimethyl-4-nitro-1-phenyl-butan-1-one 
• 110466-48-3 3-acetyl-3-methyl-1-phenylpentane-1,4-dione 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 128260-03-7 4,4-ethylenedioxy-2-methyl-4-phenylbutan-2-ol 
• 128260-00-4 2,2-dimethyl-4-oxo-4-phenylbutanal 
• 5650-07-7 3-methyl-1-phenyl-but-2-en-1-one 
• 81396-48-7 2-aceto-1,4-diphenylbutane-1,4-dione 
• 52313-43-6 3-acetyl-1-phenyl-pentane-1,4-dione 
• 110466-50-7 2,3-Dimethyl-5-phenyl-3,4-dihydro-2H-pyrrol-2-ol 

Relevant academic research and scientific papers

Five-membered heteroaromatic ring derivative as well as preparation method and application thereof

The invention discloses a five-membered heteroaromatic ring derivative and a preparation method and application thereof, and the compound has obvious inhibition on DHODH. The blocking effect can be used as DHODH specific inhibitor, can be used for preparing medicines for treating diseases caused by fungal infection, can be used for preparing agricultural fungicides, and has wide application prospects.

Aerobic synthesis of pyrroles and dihydropyrroles from imines: Palladium(II)-catalyzed intramolecular C-H dehydrogenative cyclization

sp3ectacularly mild! An efficient PdII-catalyzed intramolecular dehydrogenative cyclization of imines affords (dihydro)pyrrole products using molecular oxygen as the sole oxidant. This mild formal sp 3-C-H functionalization allows rapid and atom-economical assembly of (dihydro)pyrrole rings from inexpensive and readily available allylamines and ketones. A broad range of functional groups are tolerated. Copyright

Synthesis of pyrrole derivatives by palladium-catalyzed cyclization of γ,δ-unsaturated ketone o-pentafluorobenzoyloximes

Various pyrrole derivatives are synthesized from γ,δ-unsaturated ketone O-pentafluorobenzoyloximes by treatment with catalytic amounts of Pd(PPh3)4 and triethylamine via alkylideneaminopalladium(II) intermediates generated by oxidative addition of the oximes to the Pd(0) complex.

Synthesis of pyridine and isoquinoline derivatives by the palladium-catalyzed cyclization of olefinic ketone O-pentafluorobenzoyloximes

Pyridines and isoquinolines are synthesized from olefinic ketone O-pentafluorobenzoyloximes by treatment with a catalytic amount of Pd(PPh3)4 in the presence of (n-Bu)4NCl and triethylamine.

Synthesis and Chemistry of Azolenines. Part 16. Preparation of both 3H- and 2H-Pyrroles from 2,2-Disubstituted 1,4-Diketones via the Paal-Knorr Reaction, and Isolation of Intermediate 2-Hydroxy-3,4-dihydro-2H-pyrroles

Treatment of 2,2-disubstituted 1,4-diketones (1) with liquid ammonia gives high yields of isolable isomeric 2-hydroxy-3,4-dihydro-2H-pyrroles (10) and (11), many of which may be dehydrated to 3H-pyrroles (2) together, in certain cases, with isomeric methylene-pyrrolines (14) and (15).When heated in acetic acid with ammonium acetate, the diketones (1) yield 2H-pyrroles (18), sometimes in admixture with 3H-pyrroles (2) from which they are formed by rearrangement.The diketones (1), including some novel examples, are prepared from nitro-ketones (6) by the Nef reaction, as well as other methods.

THE SYNTHESIS AND CHEMISTRY OF AZOLENINES. PART 12. ISOLATION OF INTERMEDIATE 2-HYDROXY-3,4-DIHYDRO-2H-PYRROLES IN THE PAAL-KNORR 1H-PYRROLE SYNTHESIS.

Treatment of 1,4-diketones with liquid ammonia gives high yields of isolable 2-hydroxy-3,4-dihydro-2H-pyrrole intermediates.These intermediates, which do not appear to have been observed previously in the Paal-Knorr synthesis with ammonia, have been fully characterized by i.r. and 1H and 13C n.m.r. spectroscopy; in most cases they decompose quantitatively into 1H-pyrroles on standing.The intermediate from hexane-2,4-dione may also be prepared using concentrated aqueous ammonia.

Novel Synthesis of 3H-Pyrroles, and Novel Intermediates in the Paal-Knorr 1H-Pyrrole Synthesis: 2-Hydroxy-3,4-dihydro-2H-pyrroles from 1,4-Diketones and Liquid Ammonia

Reaction of 2,2-dimethyl-1,4-diketones with liquid ammonia gives high yields of isolable 2-hydroxy-3,4-dihydro-2H-pyrroles (3) and (5) which are readily dehydrated to give separable mixtures of 3H-pyrroles and methylenedihydropyrroles, while less-substituted 1,4-diketones give analogous hydroxy-compounds (4) and (6) which are hitherto-unsuspected intermediates in the Paal-Knorr 1H-pyrrole synthesis.