110475-21-3

Upstream product

• 4949-44-4 ethyl propanoylacetate 
• 7803-57-8 hydrazine hydrate 

Downstream Products

• 24342-04-9 methyl pent-2-ynoate 
• 1207259-37-7 1-(2,4-dichloro-phenyl)-2-(5-ethyl-2H-pyrazol-3-yloxy)-propan-1-one 

Relevant academic research and scientific papers

A systematic exploration of nickel-pyrazolinato chemistry with alkali metals: New cages from serendipitous assembly

The preparation and properties of fourteen novel paramagnetic [NiIIx] aggregates bridged by pivalate, pyrazolinolate and in most cases hydroxide are reported. A rich structural diversity has been achieved by changing the nature of the alkali of the base used during the synthesis, leading to the nuclearities [NiII4NaI4] (2, 3, 4), [NiII5-NAI4] (5, 6, 7), [NiII5LiI6] (8), [NiII8MI2] (M = K (9, 10), Rb (11, 12), Cs (13, 14) and [NiII8] (15). All compounds have been characterised by single-crystal X-ray diffraction; however, full crystallographic details are given only for the representative molecules [Ni4Na4- (fpo)4(piv)8(Hpiv)8] (2), [Ni5Na4(OH)2- (mpo)4(piv)8(Hpiv)2(MeCN)2] (5), [Ni5Li6(OH)2 (fpo)2(piv)12(Hpiv)4] (8) [Ni8K2(OH)4(ppo) 4(piv)10(Hppo)2- (Hpiv)2(MeCN)2] (9), [Ni8Rb2(OH)4- (ppo)4(piv)10(Hppo) 2(Hpiv)2(MeCN)2] (11), [Ni8Cs2(OH)4(ppo) 4(piv)10(Hppo)2- (Hpiv)2(MeCN)2] (13) and [Ni8(OH)4-(mpo)2(PhCH 2CO2)10(Hmpo)8] (15). Variable-temperature bulk magnetisation measurements have been performed for each type of complex. The [NiII4NaI4] clusters show intramolecular antiferromagnetic coupling and a spin ground state of S = 0. Complexes of the type [NiII5NaI4] also display antiferromagnetic superexchange, leading to an S=1 spin ground state. The molecule with nuclearity [NiII5LiI6], in contrast, exhibits ferromagnetic interactions, resulting in the presence of low energy states with high multiplicity, and a spin ground state S>1. The [NiII5MI2] and [NiII8] clusters have the same topology of spin carriers, which display predominantly antiferromagnetic interactions to yield a diamagnetic ground state. The coupling within these octanuclear NiII clusters is rationalised in terms of the nature of the Ni-O-Ni angles within the core.

Synthesis method of pyrazole derivative

The invention discloses a synthesis method of a pyrazole derivative 1-(3-aminophenyl)-3-ethyl-1H-pyrazol-5-ol, wherein ethyl propionylacetate is used as a starting raw material, and ring closure, condensation and reduction are performed to obtain the target product, wherein the compound is the important pharmaceutical intermediate.

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with values in the low nanomolar range (3.2-55 nM). A set of carboxylate derivatives demonstrated markedly improved in vitro metabolic stability (t1/2 > 2 h). A selected ligand showed significant in vivo efficacy with 73% of parasitemia reduction in a mouse model. Five new cocrystal structures with PvSHMT were solved at 2.3-2.6 ? resolution, revealing a unique water-mediated interaction with Tyr63 at the end of the para-Aminobenzoate channel. They also displayed the high degree of conformational flexibility of the Cys364-loop lining this channel.

Preparation method of nitrogen-containing heterocyclic compound

The invention discloses a preparation method of a nitrogen-containing heterocyclic compound 1-(3-amino-4-methylphenyl)-3-methyl-1H-pyrazole-5-ol. The target product is prepared from ethyl propionylacetate through ring closure, condensation and reduction. The compound is an important medicine intermediate.

Synthesis technology of 1-substiutted pyrazole derivative

The invention discloses a synthesis technology of a 1-substiutted pyrazole derivative 1-(3-amino-5-methylphenyl)-3-ethyl-1H-pyrazol-5-ol. The target product is prepared from ethyl propionylacetate through ring closure, condensation and reduction. The above compound is an important medicinal intermediate.

Preparation method of 1-substituted pyrazole derivative

The invention discloses a preparation method of a 1-substiutted pyrazole derivative 1-(3-aminophenyl)-3-ethyl-1H-pyrazol-5-ol. The target product is prepared from ethyl propionylacetate through ring closure, condensation and reduction. The above compound is an important medicinal intermediate.

Organic compounds

There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.

PYRAZOLE DERIVATIVE, INTERMEDIATE THEREFOR, PROCESSES FOR PRODUCING THESE, AND HERBICIDE CONTAINING THESE AS ACTIVE INGREDIENT

The present invention provides a pyrazole derivative of the general formula (1), which has an excellent efficacy as an active component for a herbicide, an intermediate for the production thereof, processes for the production thereof, and a herbicide cont