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Hedamycin, a complex class of antibiotics derived from the bacterium Streptomyces griseorubiginosus, is a potent chemotherapy agent with a broad-spectrum activity against both solid tumors and hematological malignancies. Its unique chemical structure, which includes a DNA-binding anthraquinone moiety and a flexible polypeptide chain, enables it to intercalate and bind to DNA, inhibiting DNA synthesis and leading to cell death. Although its clinical use is limited due to significant toxicity, particularly on the bone marrow, research and interest in hedamycin as a potential anticancer agent persist due to its potent anti-tumor properties.

11048-97-8

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11048-97-8 Usage

Uses

Used in Oncology:
Hedamycin is used as a chemotherapy agent for its broad-spectrum activity against various types of cancer, including solid tumors and hematological malignancies. Its unique structure allows it to bind to DNA, inhibiting DNA synthesis and leading to cell death, making it a promising candidate for cancer treatment.
Used in Drug Development:
Despite its significant toxicity, hedamycin's potent anti-tumor properties have led to ongoing research and interest in its potential as a drug candidate. Efforts are being made to develop novel drug delivery systems or modify its structure to reduce toxicity while maintaining its anti-cancer efficacy, with the aim of expanding its clinical applications.
Used in Research:
Hedamycin serves as an important subject of study in cancer research, providing insights into the mechanisms of action of DNA-intercalating agents and their potential applications in cancer treatment. Its unique structure and potent anti-tumor properties make it a valuable tool for understanding the molecular basis of cancer and developing new therapeutic strategies.

Check Digit Verification of cas no

The CAS Registry Mumber 11048-97-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,4 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 11048-97:
(7*1)+(6*1)+(5*0)+(4*4)+(3*8)+(2*9)+(1*7)=78
78 % 10 = 8
So 11048-97-8 is a valid CAS Registry Number.
InChI:InChI=1/C41H50N2O11/c1-16-11-22-30(37-28(16)24(44)14-27(53-37)41(6)39(54-41)36-18(3)52-36)35(48)31-29(34(22)47)20(25-13-23(42(7)8)32(45)17(2)50-25)12-21(33(31)46)26-15-40(5,43(9)10)38(49)19(4)51-26/h11-12,14,17-19,23,25-26,32,36,38-39,45-46,49H,13,15H2,1-10H3

11048-97-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 10-[4-(dimethylamino)-5-hydroxy-4,6-dimethyloxan-2-yl]-8-[4-(dimethylamino)-5-hydroxy-6-methyloxan-2-yl]-11-hydroxy-5-methyl-2-[2-methyl-3-(3-methyloxiran-2-yl)oxiran-2-yl]naphtho[2,3-h]chromene-4,7,12-trione

1.2 Other means of identification

Product number -
Other names Antibiotic B26,158

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:11048-97-8 SDS

11048-97-8Upstream product

11048-97-8Downstream Products

11048-97-8Related news

Regular paperThe interaction of Hedamycin (cas 11048-97-8) and DC92-B in a sequence selective manner with DNA in intact human cells08/25/2019

The sequence specificity of the pluramycin antibiotics hedamycin and DC92-B, was established in intact human cells using a linear amplification system. In this system an oligonucleotide primer is extended by Taq DNA polymerase up to a damage site. The products are run on a DNA sequencing gel and...detailed

The structure of the antibiotic Hedamycin (cas 11048-97-8)—III: 13C NMR spectra of Hedamycin (cas 11048-97-8) and kidamycin108/22/2019

The 13C NMR spectra of hedamycin, kidamycin and some of their derivatives have been fully assigned. Proton coupling constants and 13C NMR acetylation shifts indicate that the conformations of the highly substituted tetrahydropyran rings in solution are chair forms for ring E, as well as for ring...detailed

The structure of the antibiotic Hedamycin (cas 11048-97-8)-II : Comparison of Hedamycin (cas 11048-97-8) and kidamycin08/18/2019

A detailed spectral comparison between kidamycin 1 and hedamycin 13 shows that the two antibiotics have almost identical structures. However, the olefinic side chain at C-2 of kidamycin is replaced in hedamycin by a 2,3,4,5-diepoxy-2-hexyl group.detailed

ArticleThe Hedamycin (cas 11048-97-8) Locus Implicates a Novel Aromatic PKS Priming Mechanism08/17/2019

The biosynthetic gene cluster for the pluramycin-type antitumor antibiotic hedamycin has been cloned from Streptomyces griseoruber. Sequence analysis of the 45.6 kb region revealed a variety of unique features such as a fabH homolog (KSIII), an acyltransferase (AT) gene, a set of type I polyketi...detailed

ArticleIn Vivo and In Vitro Analysis of the Hedamycin (cas 11048-97-8) Polyketide Synthase08/16/2019

SummaryHedamycin is an antitumor polyketide antibiotic with unusual biosynthetic features. Earlier sequence analysis of the hedamycin biosynthetic gene cluster implied a role for type I and type II polyketide synthases (PKSs). We demonstrate that the hedamycin minimal PKS can synthesize a dodeca...detailed

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