110483-06-2

Usage

InChI:InChI=1/C6H10F2N2/c1-2-5(10)3-6(7,8)4-9/h1,5H,3-4,9-10H2

Upstream product

• 110483-04-0 1,4-bis(tert-butylcarbamoyl)-2,2-difluoro-5-hexyne 
• 110483-02-8 2,2-difluoro-1-phthalimido-5-hexyn-4-ol 
• 110483-03-9 2,2-difluoro-1,4-diphthalimido-5-hexyne 

Relevant academic research and scientific papers

2,2-Difluoro-5-hexyne-1,4-diamine: A potent enzyme-activated inhibitor of ornithine decarboxylase

2,2-Difluoro-5-hexyne-1,4-diamine was prepared in an eight-step sequence from ethyl 2,2-difluoro-4-pentenoate and tested as an inhibitor of mammalian ornithine decarboxylase. It produces a time-dependent inhibition of the enzyme in vitro which shows saturation kinetics, with K(I) = 10 μM and τ( 1/2 ) = 2.4 min. In rats, it produces a rapid, long-lasting, and dose-dependent decrease of ornithine decarboxylase activity in the ventral prostate, testis, and thymus. In contrast with the nonfluorinated analogue 5-hexyne-1,4-diamine (Danzin et al. Biochem. Pharmacol. 1983, 32, 941), 2,2-difluoro-5-hexyne-1,4-diamine is not a substrate of mitochondrial monoamine oxidase.

Fluorinated diaminoalkyne derivatives

Novel fluorinated diaminoalkyne derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: STR1 wherein R represents C1 -C4 alkyl, or preferably, hydrogen.