1104889-15-7Relevant academic research and scientific papers
Tetracyclic sulfones as potent γ-secretase inhibitors: Synthesis and structure-activity relationship studies
Sasikumar,Burnett, Duane A.,Asberom, Theodros,Wu, Wen-Lian,Bennett, Chad,Cole, David,Xu, Ruo,Greenlee, William J.,Clader, John,Zhang, Lili,Hyde, Lynn
scheme or table, p. 3645 - 3648 (2010/09/17)
Complex tetracyclic sulfones were designed as γ-secretase inhibitors and a stereoselective synthesis was achieved. γ-Secretase activity was seen predominately in the (-) enantiomeric series. Compounds such as 2a and 2b showed remarkable in vitro and in vivo potency.
BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS
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Page/Page column 454; 469, (2009/03/07)
Disclosed are novel gamma secretase inhibitors of the formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, wherein L1, n, X, Ar, Y, Z, Q, and Q1 are as defined herein. Also disclosed are methods for inhibiti
