110508-07-1

Upstream product

• 186581-53-3 diazomethane 
• 146384-37-4 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-cyano-(4E)-pentene 
• 103347-14-4 4-(bromomethyl)-1-chloro-2-methoxybenzene 
• 87763-64-2 (2S,3R)-2-Methoxy-3-methyl-pent-4-enoic acid methyl ester 
• 109864-22-4 (3R,4S)-1-(4-Chloro-3-methoxy-phenyl)-1-(diphenyl-phosphinoyl)-3-methoxy-4-methyl-hex-5-en-2-one 
• 109864-22-4 1-(4-Chloro-3-methoxy-phenyl)-1-(diphenyl-phosphinoyl)-3-methoxy-4-methyl-hex-5-en-2-one 
• 73909-16-7 2-chloro-5-methylanisole 
• 106315-61-1 (E)-(3S,4R)-6-(4-Chloro-3-methoxy-phenyl)-4-methoxy-3-methyl-hex-5-enoic acid 
• 116022-15-2 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-(4E)-penten-1-ol 
• 116022-17-4 5-(4'-chloro-5'-methoxyphenyl)-(2S)-methyl-(3R)-methoxy-1-tosyloxy-(4E)-pentene 
• 107494-32-6 (3R,4S)-3-hydroxy-4-methyldihydrofuran-2(3H)-one 
• 110463-12-2 4-chloro-3-methoxyphenylmethyl(triphenyl)phosphonium bromide 
• 159108-92-6 (+)-(1,2-syn)-3-(tert-butyldimethylsiloxy)-1-methoxy-1-(4-methoxyphenyl)-2-methylpropane 
• 159108-94-8 (+)-(3,4-syn)-4-methoxy-4-(4-methoxyphenyl)-3-methylbutanenitrile 

Downstream Products

• 109864-25-7 (E)-(3S,4S)-6-(4-Chloro-3-methoxy-phenyl)-2-[1-hydroxy-meth-(Z)-ylidene]-4-methoxy-3-methyl-hex-5-enoic acid methyl ester 

Relevant academic research and scientific papers

Formal total syntheses of (-)-oudemansins A, B and X based on a lipase-catalysed hydrolysis of an acetate

A highly stereoselective synthesis of versatile chiral synthons possessing two stereogenic centres and based on the enzyme hydrolysis of an acetate, has been achieved and an application of this to the formal total synthesis of (-)-oudemansins A (1), B (2)

A highly stereoselective synthesis of the versatile chiral synthons possessing two stereogenic centers, the formal total syntheses of (-)- oudemansins A, B, and X

A highly stereoselective synthesis of the versatile chiral synthons possessing two stereogenic centers. (2R,3R)-8 and (2S,3S)-8 was achieved and the application of (2R,3R)-8 into the formal total syntheses of (-)- oudemansins A(2), B(3), and X(4) were des

A formal total synthesis of (-)-oudemansin B

(-)-Oudemansin B (1) was formally synthesized from the (2S,3R)-3-hydroxy lactone 5 obtained by microbial asymmetric reduction as a key step.

SYNTHESIS OF OUDEMANSINS A AND B

Efficient, stereocontrolled syntheses of the antifungal metabolites oudemansin A and B are described.