11052-72-5

Basic information

• Product Name: OLIGOMYCIN C
• Synonyms: OLIGOMYCIN C;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Oligomycin A, 12-deoxy-;12-Deoxyoligomycin A;Oligmycin C
• CAS NO: 11052-72-5
• Molecular Formula: C45H74O10
• Molecular Weight: 775.06
• EINECS: 234-276-0
• Product Categories: Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;AntifungalAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Macrolides;Mechanism of Action;Spectrum of Activity
• Mol File: 11052-72-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 876.2°Cat760mmHg
• Flash Point: 249.4°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: −20°C
• Solubility: Soluble in DMSO
• PKA: 13.49±0.70(Predicted)
• Merck: 13,6902
• CAS DataBase Reference: OLIGOMYCIN C(CAS DataBase Reference)
• NIST Chemistry Reference: OLIGOMYCIN C(11052-72-5)
• EPA Substance Registry System: OLIGOMYCIN C(11052-72-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RIDADR: 2811
• RTECS: RK3335000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 11052-72-5(Hazardous Substances Data)

Usage

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.

Uses

Different sources of media describe the Uses of 11052-72-5 differently. You can refer to the following data:
1. Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
2. Oligomycin C is an ATP synthetase and RVD inhibitor.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors

references

[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.

InChI:InChI=1/C45H74O10/c1-12-35-17-15-13-14-16-26(3)39(48)30(7)41(50)32(9)43(52)33(10)42(51)31(8)40(49)27(4)18-21-38(47)53-44-29(6)36(20-19-35)54-45(34(44)11)23-22-25(2)37(55-45)24-28(5)46/h13-15,17-18,21,25-37,39-40,43-44,46,48-49,52H,12,16,19-20,22-24H2,1-11H3