110522-08-2Relevant academic research and scientific papers
SYNTHESIS OF 3,6-DISUBSTITUTED &β-CARBOLINES WHICH POSSESS EITHER BENZODIAZEPINE ANTAGONIST OR AGONIST ACTIVITY
Hagen, Timothy J.,Guzman, Filadelfo,Schultz, Christopher,Cook, James M.,Skolnick, Phil,Shannon, Harlan E.
, p. 2845 - 2855 (2007/10/02)
A series of 3-substituted and 3,6-disubstituted β-carbolines have been synthesized.These compounds have been screened in vitro in order to determine the size of substituents which benzodiazepine receptors will tolerate at positions -3 and -6 of the β-carboline nucleus.It has been found that the receptor will tolerate ester alkyl groups at position-3 as large as cyclohexyl 1g but not as large as adamantyl 5d.Moreover, N-aryl substituents as large as naphthobenzylamino 8b can be introduced at position-6 without significant loss of receptor binding affinity.
