110538-85-7Relevant academic research and scientific papers
Prolinol as a Chiral Auxiliary in Organophosphorus Chemistry
Kozio?, Anna E.,W?odarczyk, Adam
, p. 1931 - 1941 (2021/04/06)
Several strategies for the development of the synthesis of P-chiral organophosphorus compounds with (L)-prolinol as a source of chirality have been examined. A reaction of L-prolinol with a set of different alkyl/arylphosphonous acid diamides led in most of the cases to the quantitative formation of the appropriate bicyclic oxazaphospholidines with complete diastereo and enantioselectivity. The latter were reacted with BH3 complex and the formed borane analogues were submitted to structural modifications leading to tertiary phosphine-boranes. Additionally, the effectiveness of oxazaphospholidines as ligands in transition metal asymmetric catalysis has been tested in hydrogenation of dehydroaminoacid esters and imine.
The reactivity of arylphosphorus acid amides under Birch reduction conditions
Stankevic, Marek,Wlodarczyk, Adam,Nieckarz, Damian
, p. 4351 - 4371 (2013/07/26)
Several classes of arylphosphorus acid amides have been tested in reactions with alkali metal solutions in liquid ammonia. The outcomes of such reactions depend on the structures of the starting materials. Generally, two processes-Birch reduction or cleavage of the P-aryl bond-can be operative. Diarylphosphinic amides tend to undergo double Birch reduction to afford bis(cyclohexadienyl)phosphinic amides. Copyright
