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1105568-81-7

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1105568-81-7 Usage

Uses

A Sesamin (S280500) metabolite which acts as antioxidant in the liver.

Check Digit Verification of cas no

The CAS Registry Mumber 1105568-81-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,5,5,6 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1105568-81:
(9*1)+(8*1)+(7*0)+(6*5)+(5*5)+(4*6)+(3*8)+(2*8)+(1*1)=137
137 % 10 = 7
So 1105568-81-7 is a valid CAS Registry Number.

1105568-81-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name epi-Sesamin Monocatechol

1.2 Other means of identification

Product number -
Other names 4-[(3aR,6aR)-6-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]benzene-1,2-diol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1105568-81-7 SDS

1105568-81-7Downstream Products

1105568-81-7Relevant articles and documents

First chemical synthesis of antioxidative metabolites of sesamin

Urata, Hidehito,Nishioka, Yuka,Tobashi, Takafumi,Matsumura, Yasuo,Tomimori, Namino,Ono, Yoshiko,Kiso, Yoshinobu,Wada, Shun-Ichi

, p. 1611 - 1612 (2008)

The first chemical synthesis of two metabolites ((1R,2S,5R,6S)-6-(3,4- dihydroxyphenyl)-2-(3,4-methylenedioxyphenyl)-3,7-dioxabicyclo[3,3,0]octane (SC-1) and (1R,2S,5R,6S)-2,6-bis(3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3,3,0] octane (SC-2)) of sesamin was achieved by a simple two-step approach from sesamin. The approach consists of acetoxylation of the methylenedioxy moiety(ies) with lead(IV) tetraacetate and acid hydrolysis of the resulting hemiorthoester to SC-1 and SC-2.

Furofuran lignans as a new series of antidiabetic agents exerting α-glucosidase inhibition and radical scarvenging: Semisynthesis, kinetic study and molecular modeling

Worawalai, Wisuttaya,Doungwichitrkul, Titiruetai,Rangubpit, Warin,Taweechat, Panyakorn,Sompornpisut, Pornthep,Phuwapraisirisan, Preecha

, p. 783 - 793 (2019)

A new series of furofuran lignans containing catechol moiety were prepared from the reactions between lignans and a variety of phenolics. All 22 products obtained were evaluated against three different α-glucosidases (maltase, sucrase and Baker's yeast glucosidase) and DPPH radical. Of furofuran lignans evaluated, β-14, having two catechol moieties and one acetoxy group, was the most potent inhibitor against Baker's yeast, maltase, and sucrase with IC50 values of 5.3, 25.7, and 12.9 μM, respectively. Of interest, its inhibitory potency toward Baker's yeast was 28 times greater than standard drug, acarbose and its DPPH radical scavenging (SC50 11.2 μM) was 130 times higher than commercial antioxidant BHT. Subsequent investigation on mechanism underlying the inhibitory effect of β-14 revealed that it blocked Baker's yeast and sucrase functions by mixed-type inhibition while it exerted non-competitive inhibition toward maltase. Molecular dynamics simulation of the most potent furofuran lignans (4, α-8b, α-14, and β-14) with the homology rat intestinal maltase at the binding site revealed that the hydrogen bond interactions from catechol, acetoxy, and quinone moieties of furofuran lignans were the key interaction to bind tightly to α-glucosidase. The results indicated that β-14 possessed promising antidiabetic activity through simultaneously inhibiting α-glucosidases and free radicals.

Identification of the metabolites of episesamin in rat bile and human liver microsomes

Tomimori, Namino,Nakai, Masaaki,Ono, Yoshiko,Kitagawa, Yoshinori,Kiso, Yoshinobu,Shibata, Hiroshi

experimental part, p. 709 - 716 (2012/09/22)

Episesamin is an isomer of sesamin, resulting from the refining process of non-roasted sesame seed oil. Episesamin has two methylendioxyphenyl groups on exo and endo faces of the bicyclic skeleton. The side methylendioxyphenyl group was metabolized by cyt

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