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1105571-65-0

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1105571-65-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1105571-65-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,5,5,7 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1105571-65:
(9*1)+(8*1)+(7*0)+(6*5)+(5*5)+(4*7)+(3*1)+(2*6)+(1*5)=120
120 % 10 = 0
So 1105571-65-0 is a valid CAS Registry Number.

1105571-65-0Downstream Products

1105571-65-0Relevant articles and documents

Xanthine oxidase inhibitory properties and anti-inflammatory activity of 2-amino-5-alkylidene-thiazol-4-ones

Smelcerovic, Zaklina,Veljkovic, Andrej,Kocic, Gordana,Yancheva, Denitsa,Petronijevic, Zivomir,Anderluh, Marko,Smelcerovic, Andrija

, p. 73 - 81 (2015/02/19)

Thirty 2-amino-5-alkylidene-thiazol-4-ones were assayed for inhibitory activity against commercial enzyme xanthine oxidase (XO) in vitro and XO in rat liver homogenate as well as for anti-inflammatory response on human peripheral blood mononuclear cells (PBMCs). 4-((2-Benzylamino-4-oxothiazol-5(4H)-ylidene)-methyl)benzonitrile showed the most potent inhibitory effect against commercial XO (IC50 = 17.16 μg/mL) as well as against rat liver XO (IC50 = 24.50 μg/mL). All compounds containing the 4-cyanobenzylidene group or (indol-3-yl)methylene group at the position 5 of thiazol-4-one moiety were moderately potent inhibitors of commercial XO. The assayed compounds were docked into the crystal structures of XO enzyme complexes with three diverse inhibitors (PDB codes: 1FIQ, 1VDV, and 1V97) using OEDocking software. Our results strongly point to a correlation between the data on inhibitory activity against commercial XO and data on antioxidant activity of studied compounds, screened using a lipid peroxidation (LP) method. 2-(Benzylamino)-5-((thiophen-2-yl)methylene)thiazol-4(5H)-one showed the highest anti-inflammatory response on PBMCs, exerted most probably through the NF-κB inhibition. Studied 2-amino-5-alkylidene-thiazol-4-ones obey the "Rule of five" and meet all criteria for good solubility and permeability.

Three-component one-pot synthetic route to 2-amino-5-alkylidene-thiazol-4-ones

Anderluh, Marko,Juki?, Marko,Petri?, Rok

experimental part, p. 344 - 350 (2009/04/06)

A fast and straightforward three-component reaction to 2-amino-5-alkylidene-thiazol-4-ones is described. The one-pot methodology, reported for the first time, involves Knoevenagel condensation of aromatic aldehydes and rhodanine followed by displacement o

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