1105662-87-0

Basic information

• Product Name: 1-Boc-3-methoxycarbonylme...
• Synonyms: 1-Boc-3-methoxycarbonylme...;1-Boc-3-MethoxycarbonylMethylene-azetidine;tert-butyl 3-(2-Methoxy-2-oxoethylidene)azetidine-1-carboxylate;1-Azetidinecarboxylic acid, 3-(2-Methoxy-2-oxoethylidene)-, 1,1-diMethylethyl ester;1,3-Azetidinedicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester
• CAS NO: 1105662-87-0
• Molecular Formula: C₁₁H₁₇NO₄
• Molecular Weight: 227.25698
• Mol File: 1105662-87-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 303.271 °C at 760 mmHg
• Flash Point: 137.214 °C
• Appearance: /
• Density: 1.219 g/cm³
• Storage Temp.: 2-8°C
• PKA: -1.69±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-3-methoxycarbonylme...(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-methoxycarbonylme...(1105662-87-0)
• EPA Substance Registry System: 1-Boc-3-methoxycarbonylme...(1105662-87-0)

Safety Data

• Hazardous Substances Data: 1105662-87-0(Hazardous Substances Data)

Usage

Uses

tert-Butyl 3-(2-methoxy-2-oxoethylidene)azetidine-1-carboxylate is a useful intermediate used in the preparation of spirocyclic β-proline esters that functions as building blocks for medicinal chemistry.

Upstream product

• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 1067-74-9 Methyl diethylphosphonoacetate 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 1105662-89-2 tert-butyl 3-amino-3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate 
• 55164-54-0 1,5-dihydro-1-methyl-4-phenyl-2H-pyrrol-2-one 
• 402938-21-0 (Z)-methyl 3-[[(1,1-dimethylethoxycarbonyl)methylamino]methyl]-3-phenyl-2-propenoate 

Relevant articles and documents

Synthesis of oxetane/azetidine containing spirocycles

Oxetane-benzopyran spirocycles were synthesised via a palladium catalysed cyclisation-cross coupling cascade reaction whilst oxetane/azetidine-pyrrolidino isoindolone spirocycles were synthesised via a silver catalysed 1,3-dipolar cycloaddition reaction f

Rhodium catalyzed C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates and analogs

The C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates with aryl boronic acids catalyzed by a rhodium complex was studied with a "conjugate addition/β-C cleavage/protonation" strategy.

Furo-3-carboxamide derivatives and methods of use

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.