1105662-87-0

Usage

Uses

Used in Medicinal Chemistry:
1-Boc-3-methoxycarbonylme... is used as a key intermediate for the preparation of spirocyclic β-proline esters, which are essential building blocks in the development of novel pharmaceutical compounds. These spirocyclic β-proline esters are known to possess diverse biological activities and are often found in the core structures of various bioactive molecules, making them valuable for the design and synthesis of new drugs.
In the pharmaceutical industry, 1-Boc-3-methoxycarbonylme... is used as a synthetic precursor for the development of innovative therapeutic agents targeting a wide range of diseases and conditions. The compound's unique structure allows for the creation of complex molecular architectures that can be tailored to interact with specific biological targets, such as enzymes, receptors, or ion channels, with high selectivity and potency.
Furthermore, the use of 1-Boc-3-methoxycarbonylme... in medicinal chemistry enables researchers to explore new avenues in drug discovery, potentially leading to the development of more effective and safer treatments for various medical conditions. By leveraging the compound's unique properties, chemists can design and synthesize novel drug candidates with improved pharmacokinetic and pharmacodynamic profiles, ultimately contributing to the advancement of healthcare and the well-being of patients worldwide.

Upstream product

• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 1067-74-9 Methyl diethylphosphonoacetate 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 1105662-89-2 tert-butyl 3-amino-3-(2-methoxy-2-oxo-ethyl)azetidine-1-carboxylate 
• 55164-54-0 1,5-dihydro-1-methyl-4-phenyl-2H-pyrrol-2-one 
• 402938-21-0 (Z)-methyl 3-[[(1,1-dimethylethoxycarbonyl)methylamino]methyl]-3-phenyl-2-propenoate 

Relevant academic research and scientific papers

Synthesis of oxetane/azetidine containing spirocycles

Oxetane-benzopyran spirocycles were synthesised via a palladium catalysed cyclisation-cross coupling cascade reaction whilst oxetane/azetidine-pyrrolidino isoindolone spirocycles were synthesised via a silver catalysed 1,3-dipolar cycloaddition reaction f

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chemistry optimization and biological profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogues followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

Rhodium catalyzed C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates and analogs

The C-C bond cleavage/coupling of 2-(azetidin-3-ylidene)acetates with aryl boronic acids catalyzed by a rhodium complex was studied with a "conjugate addition/β-C cleavage/protonation" strategy.

Furo-3-carboxamide derivatives and methods of use

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Synthesis of 6-Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery

New scaffolds for drug discovery, 6-azaspiro[4.3]alkanes, have been synthesized in two steps from four-membered-ring ketones: cyclobutanone, thienone, N-Boc-azetidinone (Boc = tert-butoxycarbonyl), etc. The key transformation was the reaction between electron-deficient exocyclic alkenes and an in-situ generated N-benzylazomethine ylide.

FURO-3-CARBOXAMIDE DERIVATIVES AND METHODS OF USE

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.

HETEROCYCLIC COMPOUNDS USEFUL AS MK2 INHIBITORS

The present invention describes tetracyclic compounds of formula (IA) or (IB), wherein the symbols R, X, A, Y, R2, R3 and D are as defined in the specification, their use in the treatment of certain diseases, e.g. depending on MK-2 or TNF activity, and wa