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1105662-95-0

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1105662-95-0 Usage

Description

2,5-Diazaspiro[3.5]nonane-2-carboxylic acid, 6,8-dioxo-, 1,1-diMethylethyl ester, also known as Tert-butyl 6,8-dioxo-2,5-diazaspiro[3.5]nonane-2-carboxylate, is a complex organic compound with a unique molecular structure. It is characterized by its spirocycle, which consists of a nitrogen-containing ring fused to a nonane ring. The molecule also features a carboxylic acid group, an ester group, and two oxygen atoms at the 6 and 8 positions. 2,5-Diazaspiro[3.5]nonane-2-carboxylic acid, 6,8-dioxo-, 1,1-diMethylethyl ester is known for its potential applications in the pharmaceutical industry, particularly in the development of novel drugs.

Uses

Used in Pharmaceutical Industry:
2,5-Diazaspiro[3.5]nonane-2-carboxylic acid, 6,8-dioxo-, 1,1-diMethylethyl ester is used as a reactant for the preparation and structure-activity relationship (SAR) studies of tetracyclic MK2 (MAPKAP-K2) inhibitors. These inhibitors are of significant interest due to their potential role in the treatment of various diseases, including cancer and inflammatory disorders. The compound's unique structure allows for the development of highly specific and potent inhibitors that can modulate the activity of MK2, a key enzyme involved in cellular signaling pathways.
In the development of MK2 inhibitors, this compound serves as a key building block, enabling the synthesis of a diverse range of tetracyclic structures with varying biological activities. By understanding the structure-activity relationship of these tetracyclic compounds, researchers can optimize their potency, selectivity, and pharmacokinetic properties, ultimately leading to the development of more effective therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 1105662-95-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,0,5,6,6 and 2 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1105662-95:
(9*1)+(8*1)+(7*0)+(6*5)+(5*6)+(4*6)+(3*2)+(2*9)+(1*5)=130
130 % 10 = 0
So 1105662-95-0 is a valid CAS Registry Number.

1105662-95-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 6,8-dioxo-2,5-diazaspiro[3.5]nonane-2-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1105662-95-0 SDS

1105662-95-0Relevant articles and documents

QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS

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Page/Page column 166; 168, (2020/04/25)

The present application relates to novel quinazoline compounds as inhibitors of type I receptor tyrosine kinases, the pharmaceutical compositions comprising one or more of the compounds and salts thereof as an active ingredient, and the use of the compounds and salts thereof in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals and especially in humans.

FURO-3-CARBOXAMIDE DERIVATIVES AND METHODS OF USE

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Paragraph 0616; 0624, (2015/08/04)

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

HETEROCYCLIC COMPOUNDS USEFUL AS MK2 INHIBITORS

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Page/Page column 49, (2009/03/07)

The present invention describes tetracyclic compounds of formula (IA) or (IB), wherein the symbols R, X, A, Y, R2, R3 and D are as defined in the specification, their use in the treatment of certain diseases, e.g. depending on MK-2 or TNF activity, and wa

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