1105665-34-6Relevant articles and documents
A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes
White, Alexander R.,Kozlowski, Ryan A.,Tsai, Shiou-Chuan,Vanderwal, Christopher D.
, p. 10525 - 10529 (2017)
The ubiquitous use of π-rich five-membered heterocycles has driven the development of new methods for their synthesis for more than a century. Here, we disclose a general and reliable reaction manifold for the construction of highly substituted heterocycles through a facile Lewis-acid-catalyzed oxetane rearrangement. Notably, this methodology employs a keto-oxetane motif as a 1,4-dicarbonyl surrogate, which can be synthesized using robust alkylation or alkenylation reactions, and thus obviates the need to access 1,4-dicarbonyl compounds via umpoled starting materials. We harnessed this reactivity to generate a broad range of substituted furans and pyrroles, and extended this methodology to produce benzo-fused versions thereof.
Synthesis of oxetane/azetidine containing spirocycles
Hamill, Rosalie,Jones, Benjamin,Pask, Christopher M.,Sridharan, Visuvanathar
supporting information, p. 1126 - 1129 (2019/03/26)
Oxetane-benzopyran spirocycles were synthesised via a palladium catalysed cyclisation-cross coupling cascade reaction whilst oxetane/azetidine-pyrrolidino isoindolone spirocycles were synthesised via a silver catalysed 1,3-dipolar cycloaddition reaction f
FURO-3-CARBOXAMIDE DERIVATIVES AND METHODS OF USE
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Paragraph 0620; 0630, (2015/08/04)
Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
