1105681-99-9Relevant academic research and scientific papers
Synthesis of novel substituted 7-(benzylideneamino)-4-methyl-2H-chromen-2- one derivatives as anti-inflammatory and analgesic agents
Ronad, Pradeepkumar M.,Dharbamalla, Satyanarayana,Hunshal, Rajesh,Maddi, Veeresh
, p. 696 - 700 (2008)
A series of novel Schiff' base-containing a 7-amino-4-methylcoumarin moiety have been synthesized III a-l, characterized by spectroscopic data and studied for their anti-inflammatory and analgesic activity. The results of the anti-inflammatory and analgesic activity evaluation of 7-(substituted benzylideneamino)-4-methyl-2H-chromen-2-one derivatives III a-l proved to be comparable or more potent with respect to the reference drugs. In particular, compounds 7-(4-chlorobenzylideneamino)-4-methyl-2H-chromen-2-one III f, 7-(2,4-dichlorobenzylideneamino)-4-methyl-2H-chromen-2-one III g and 7-(4-bromobenzylideneamino)-4-methyl-2H-chromen-2-one III h exhibited potent anti-inflammatory and analgesic activity.
