110577-70-3

Usage

Uses

Used in Organic Synthesis:
2-(4-methoxybenzyl)-3,3-dimethylbutanoic acid is used as a key intermediate for the synthesis of various organic compounds due to its unique structural features, which can be further modified or functionalized in chemical reactions to yield a range of products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(4-methoxybenzyl)-3,3-dimethylbutanoic acid is used as a precursor in the development of new drugs. Its complex structure allows for the exploration of its potential as a therapeutic agent or as a component in the formulation of novel pharmaceuticals, contributing to drug discovery efforts.

Upstream product

• 924264-87-9 C₁₄H₁₈O₃ 

Relevant academic research and scientific papers

Structural requirements for substrate in highly enantioselective hydrogenation over the cinchonidine-modified Pd/C

Relationship between substrate structure and enantioselectivity is studied for the asymmetric hydrogenation of 42 different (E)-α, β-disubstituted acrylic acids (propenoic acids) over cinchonidine-modified Pd/C. The β-phenyl group is indispensable for high enantioselectivity of α-phenylcinnamic acid (2,3-diphenylpropenoic acid, 81% ee), and substitution on this group affects markedly the selectivity. The high ee up to 92% was achieved by the β - p-alkoxyphenyl substitution, and the selectivity is ascribed mainly to stronger interaction of the substrate with the chiral modifier on the catalyst surface. In contrast, substitution on the α-phenyl group does not affect notably the enantioselectivity (80-82% ee) or even the α-phenyl group itself is not indispensable but replaceable with a properly bulky group for the high enantioselectivity.