110578-84-2Relevant academic research and scientific papers
COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NEURODEGENERATIVE DISORDERS
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, (2017/03/08)
Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.
A versatile synthesis of various substituted taurines from vicinal amino alcohols and aziridines
Chen, Ning,Jia, Weiyi,Xu, Jiaxi
experimental part, p. 5841 - 5846 (2010/03/03)
Taurine and structurally diverse substituted taurines have been synthesized by peroxyformic acid, oxidation of the thiazolidine-2-thione intermediates generated from, vicinal amino alcohols or aziridines and carbon disulfide. The stereochemistry and mechanisms of the reactions are disscussed. The method is a salt-free and versatile route, convenient in terms of purification, and can be used to synthesize optically active substituted taurines.
Efficient synthesis of taurine and structurally diverse substituted taurines from aziridines
Hu, Libo,Zhu, Hui,Du, Da-Ming,Xu, Jiaxi
, p. 4543 - 4546 (2008/02/05)
(Chemical Equation Presented) Taurine and substituted taurines were synthesized efficiently from aziridines via ring-opening reaction with thioacetic acid, oxidation with performic acid, and hydrolysis in hydrochloric acid. The current method shows more benefit in purification and efficiency in the preparation of taurine and structurally diverse 2-substituted, 2,2-disubstituted, and 1,2-, 2,2-, and 2,N-alkylene taurines.
Novel antifungal β-amino acids: Synthesis and activity against Candida albicans
Mittendorf, Joachim,Kunisch, Franz,Matzke, Michael,Militzer, Hans-Christian,Schmidt, Axel,Schoenfeld, Wolfgang
, p. 433 - 436 (2007/10/03)
A series of novel β-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. β-Amino acid 21 (BAY 10-8888/PLD-118) revealed the most favourable activity-tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.
Amino-sulfonation of alkenes in a three-component reaction
Cordero, Franca M.,Cacciarini, Martina,Machetti, Fabrizio,De Sarlo, Francesco
, p. 1407 - 1411 (2007/10/03)
2-Aminoalkanesulfonic acids have been synthesized by a three-component alkene/SO3·-DMF/acetonitrile reaction, followed by hydrolysis. Trifluoromethanesulfonic acid was added to the amino-sulfonation mixture to accelerate the reaction and prevent the competitive formation of by-products. The reported two-step procedure provided a concise and versatile approach to new analogues of the natural amino acid taurine. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
Synthesis of taurine analogues. Part 1: 2-Aminosulfonic acids from alkene-sulfur monochloride adducts
Machetti, Fabrizio,Cacciarini, Martina,Catrambone, Fernando,Cordero, Franca M.,Romoli, Simone,De Sarlo, Francesco
, p. 120 - 121 (2007/10/03)
(±)Trans-2-aminocyclohexanesulfonic acid and (±)trans-2- aminocyclopentanesulfonic acid were prepared respectively from cyclohexene and cyclopentene by sulfur monochloride addition, followed by oxidation to 2- chlorosulfonic acid and substitution of chlor
