110590-60-8

Basic information

• Product Name: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG
• Synonyms: H-CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG-OH;LAMININ FRAGMENT 925-933;LAMININ NONAPEPTIDE;LAMININ B1 CHAIN FRAGMENT (925-933);CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG;CDPGYIGSR;cys-ser-arg-ala-arg-lys-gln-ala-ala-*ser-ile-lys-;Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg (1)
• CAS NO: 110590-60-8
• Molecular Formula: C40H62N12O14S
• Molecular Weight: 967.06
• EINECS: 202-005-5
• Product Categories: Neuroscience
• Mol File: 110590-60-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.54±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• Solubility: Soluble in 5% acetic acid.
• PKA: 3.23±0.10(Predicted)
• CAS DataBase Reference: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG(CAS DataBase Reference)
• NIST Chemistry Reference: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG(110590-60-8)
• EPA Substance Registry System: CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG(110590-60-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 110590-60-8(Hazardous Substances Data)

Usage

Uses

Derived from residues 925-933 of human laminin B1, this peptide binds the laminin receptor, Inhibits experimental metastasis. find useful for product applications. And it is also used in Western Blot, Blocking Peptides, Dot Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Flow Cytomety, Cell Culture.

Biological Activity

laminin (925-933) is a peptide(cys-asp-pro-gly-tyr-ile-gly-ser-arg) derived from residues 925-933 of the laminin b1 chain that binds to the laminin receptor.laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. they have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly a, b1, and b2, respectively)the laminin beta 1 chain has 7 structurally distinct domains, which it shares with other beta chain isomers. laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from engelbreth-holm-swarm (ehs) tumor. a sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.figure1 structure of lamininfigure2 formula of lamininb1 (925-933)

references

1.Ikonen J, Pikkarainen T, Savolainen ER, Tryggvason K (Feb 1989). "A Hpa I polymorphism in the human laminin B1 chain gene on 7q22". Nucleic Acids Res 17 (1): 473.2.Roche KB, Moore JW, Surana RB, Wilson BE (May 1989). "Aortic root dilatation associated with partial trisomy 7(q31.2----qter)". Pediatr Cardiol 10 (1): 53–5.3.Bonneau D, Huret JL, Godeau G, Couet D, Putterman M, Tanzer J, Babin P, Larregue M (Sep 1991). "Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype". Hum Genet 87 (3): 317–9.