110613-13-3

Upstream product

• 90-02-8 salicylaldehyde 
• 1448308-27-7 3-{1-[(E)-2-(3-chlorophenyl)hydrazono]ethyl}-2H-chromen-2-one 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 2312-23-4 m-chlorophenylhydrazine hydrochloride 
• 110570-08-6 3-{1-[(3-Chloro-phenyl)-hydrazono]-ethyl}-4-hydroxy-chromen-2-one 
• 2555-37-5 3-acetyl-4-hydroxychromen-2-one 

Relevant academic research and scientific papers

Copper-catalyzed cyclization of 3-acylcoumarin hydrazone using air as the oxidant: Efficient synthesis of pyrazole-fused coumarin derivatives

An efficient, convenient Cu-catalyzed formation of chromeno[4,3-c]pyrazol-4(1H)-ones is reported. In this atom economic process, readily available 3-acylcoumarin hydrazone is oxidative cyclized by direct C-N bond formation. Air has been successfully used

Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates

2-Oxo-2H-chromenylpyrazolecarboxylates (8a-h and 12a-zb) have been synthesized by [3 + 2] cycloaddition of 2H-chromenophenylhydrazones (7a-h and 11a-w) with diethyl/dimethylbut-2-ynedioates. Phenylchromeno[4,3-c]pyrazol-4(1H) -ones (13i-n) were prepared from corresponding phenylhydrazones (7a-h) with catalytic amount of piperidine in presence of pyridine as a solvent at 100°C. All the synthesized compounds (8a-h, 12a-zb and 13a-n) were screened for anticancer activity against three human cancer cell lines such as prostate (DU-145), lung adenocarcinoma (A549), and cervical (HeLa) by standard MTT assay method. Further, photophysical properties (UV and fluorescence) for these compounds were discussed.