110613-30-4Relevant academic research and scientific papers
Tuning linear copolymers into protein-specific hosts
Koch, Sebastian J.,Renner, Christian,Xie, Xiulan,Schrader, Thomas
, p. 6352 - 6355 (2006)
Being picky: A new concept for selective protein recognition by artificial receptor molecules involves statistical copolymerization of simple binding monomers in defined stoichiometric ratios. As an example of its efficiency, an arginine-rich lysozyme is recognized by a bisphosphonate-rich copolymer with a remarkable Kd value of 25 nM, 100-times superior to that of cytochrome c, which is comparable in size and isoelectric point. (Chemical Equation Presented).
