110613-58-6

Upstream product

• 110613-56-4 (2R,4S,5S)-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide 
• 110613-67-7 (4S,5S)-N-isopentyl-5-<<(tert-butyloxy)carbonyl>amino>-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxamide 
• 110613-29-1 N-isopentylmethacrylamide 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 

Downstream Products

• 110613-60-0 (3S,5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-cyclohexylethyl>-3-hydroxy-3-methyldihydrofuran-2(3H)-one 
• 110613-62-2 {(S)-1-[(S)-1-[(1S,2S,4S)-1-Cyclohexylmethyl-2,4-dihydroxy-4-(3-methyl-butylcarbamoyl)-pentylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 110613-87-1 (3S,5S,1'S)-3-(benzoyloxy)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-cyclohexylethyl>-3-methyldihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

HETEROCYCLIC RENIN INHIBITORS

A renin inhibiting compound of the formula: STR1 wherein A is a substituent; R 1 is loweralkyl, loweralkenyl, alkoxyalkyl, [(alkoxy) alkoxy]alkyl, alkoxycarbonylalkyl, carboxyalkyl, (thioalkoxy) alkyl, benzyl or heterocyclic ring substituted methyl; R 2 i

Renin Inhibitors Based on Novel Dipeptide Analogues. Incorporation of the Dehydrohydroxyethylene Isostere at the Scissile Bond

The design and synthesis of renin inhibitors that incorporate the novel dipeptide isostere (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhex-1-ene-2-carboxylic acid as a transition-state analogue are described.Titanium-promoted condensation of dilithiated N-alkylmethacrylamides with protected amino aldehydes results in efficient preparation of protected dipeptide analogues 7 and 8.Incorporation of 7 into the partial sequence of angiotensinogen affords potent in vitro inhibitors of human renin.Further chemical manipulation of the unsaturated amide moiety allows the study of structure-activity relationships in both the P1' and P2' sites.Details of the syntheses, stereochemical determinations, and in vitro renin inhibition are presented.