11062-03-6
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Basic information
- Product Name: Proinsulin
- Synonyms: Proinsulin;Proinsulin, pig;Prolinsulin
- CAS NO:11062-03-6
- Molecular Formula: C398H616 N112 O120 S6
- Molecular Weight:
- EINECS: N/A
- Product Categories: N/A
- Mol File: 11062-03-6.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Proinsulin(CAS DataBase Reference)
- NIST Chemistry Reference: Proinsulin(11062-03-6)
- EPA Substance Registry System: Proinsulin(11062-03-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 11062-03-6(Hazardous Substances Data)
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11062-03-6 Usage
Clinical Use
Proinsulin, a single-chain protein of 86 amino acid residues, is synthesized in the β cells and enzymatically transformed therein to insulin. The conversion involves the cleavage of a connecting C-peptide, which contains between 30 and 35 residues, with the number and sequence varying among different species (human C-peptide consists of 35 residues). The resulting human insulin consists of two peptide chains, designated A (having 21 residues) and B (having 30 residues), which are interchain connected by two disulfide bonds. Furthermore, the A-chain also contains an intrachain disulfide bond between Cys6 and Cys11.Check Digit Verification of cas no
The CAS Registry Mumber 11062-03-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,6 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.Calculate Digit Verification of CAS Registry Number 11062-03:
(7*1)+(6*1)+(5*0)+(4*6)+(3*2)+(2*0)+(1*3)=46
46 % 10 = 6
So 11062-03-6 is a valid CAS Registry Number.
11062-03-6Upstream product
11062-03-6Downstream Products
11062-03-6Related news
Defective endoplasmic reticulum export causes Proinsulin (cas 11062-03-6) misfolding in pancreatic β cells07/16/2019
Endoplasmic reticulum (ER) homeostasis is essential for cell function. Increasing evidence indicates that, efficient protein ER export is important for ER homeostasis. However, the consequence of impaired ER export remains largely unknown. Herein, we found that defective ER protein transport cau...detailed
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