110629-33-9

Basic information

• Product Name: ethyl 2,6-dimethyl-4<(2-(4-diphenyl-methyl-1-piperazinyl)ethyl)amino>-pyridine-3-carboxylate
• Synonyms: ethyl 2,6-dimethyl-4<(2-(4-diphenyl-methyl-1-piperazinyl)ethyl)amino>-pyridine-3-carboxylate
• CAS NO: 110629-33-9
• Molecular Weight: 545.552
• Mol File: 110629-33-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2,6-dimethyl-4<(2-(4-diphenyl-methyl-1-piperazinyl)ethyl)amino>-pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,6-dimethyl-4<(2-(4-diphenyl-methyl-1-piperazinyl)ethyl)amino>-pyridine-3-carboxylate(110629-33-9)
• EPA Substance Registry System: ethyl 2,6-dimethyl-4<(2-(4-diphenyl-methyl-1-piperazinyl)ethyl)amino>-pyridine-3-carboxylate(110629-33-9)

Safety Data

• Hazardous Substances Data: 110629-33-9(Hazardous Substances Data)

Upstream product

• 841-77-0 diphenylmethylpiperazine 
• 110629-58-8 4-<(2-chloroethyl)amino>-2,6-dimethyl-3-nitropyridine 
• 15513-48-1 4-chloro-2,6-dimethyl-3-nitropyridine 
• 125742-39-4 4-<(2-hydroxyethyl)amino>-2,6-dimethyl-3-nitropyridine 

Downstream Products

• 110629-27-1 2,6-dimethyl-4-<(2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino>pyridine-3-carboxylic acid trihydrochloride dihydrate 

Relevant articles and documents

Synthesis of basic substituted pyridines: a new class of antiasthmatic- antiallergic agents

A series of pyridines were synthesized and evaluated as bronchospasmolytic / anti-allergic agents.Several of these compounds were found to: 1) inhibit the release of histamine; 2) antagonize histamine, bradykinin, LTD4 and PAF; 3) suppress the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction.The most interesting substance of this series 2,6-dimethyl-3-nitro-4pyridine 1, (HWA 214), was selected for further pharmacological evaluation.The novel, orally active agent 1 does not have such drawbacks as causing drowsiness or being effective only as a prophylactic drug, and could provide advantages over other non-sedative compounds, such as terfenadine and astemizole, in that it is water soluble and thus can be administered through inhalation or through intravenous application.Keywords: pyridines / H1-antagonistic activity / antiallergic property / antiasthmatic property