110629-36-2Relevant academic research and scientific papers
Synthesis of basic substituted pyridines: a new class of antiasthmatic- antiallergic agents
Anagnostopulos, Hiristo,Bartlett, Robert R.,Elben, Ulrich,Stoll, Paul
, p. 227 - 232 (2007/10/02)
A series of pyridines were synthesized and evaluated as bronchospasmolytic / anti-allergic agents.Several of these compounds were found to: 1) inhibit the release of histamine; 2) antagonize histamine, bradykinin, LTD4 and PAF; 3) suppress the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction.The most interesting substance of this series 2,6-dimethyl-3-nitro-4pyridine 1, (HWA 214), was selected for further pharmacological evaluation.The novel, orally active agent 1 does not have such drawbacks as causing drowsiness or being effective only as a prophylactic drug, and could provide advantages over other non-sedative compounds, such as terfenadine and astemizole, in that it is water soluble and thus can be administered through inhalation or through intravenous application.Keywords: pyridines / H1-antagonistic activity / antiallergic property / antiasthmatic property
