110629-38-4

Basic information

• Product Name: N-(2-{4-[(4-chlorophenyl)(pyridin-4-yl)methyl]piperazin-1-yl}ethyl)-2,6-dimethyl-3-nitropyridin-4-amine tetrahydrochloride
• CAS NO: 110629-38-4
• Molecular Formula: C₂₅H₂₉ClN₆O₂*4ClH
• Molecular Weight: 626.8335
• Mol File: 110629-38-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 647.3°C at 760 mmHg
• Flash Point: 345.3°C
• Vapor Pressure: 1.22E-16mmHg at 25°C
• CAS DataBase Reference: N-(2-{4-[(4-chlorophenyl)(pyridin-4-yl)methyl]piperazin-1-yl}ethyl)-2,6-dimethyl-3-nitropyridin-4-amine tetrahydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-{4-[(4-chlorophenyl)(pyridin-4-yl)methyl]piperazin-1-yl}ethyl)-2,6-dimethyl-3-nitropyridin-4-amine tetrahydrochloride(110629-38-4)
• EPA Substance Registry System: N-(2-{4-[(4-chlorophenyl)(pyridin-4-yl)methyl]piperazin-1-yl}ethyl)-2,6-dimethyl-3-nitropyridin-4-amine tetrahydrochloride(110629-38-4)

Safety Data

• Hazardous Substances Data: 110629-38-4(Hazardous Substances Data)

Upstream product

• 125742-39-4 4-<(2-hydroxyethyl)amino>-2,6-dimethyl-3-nitropyridine 
• 15513-48-1 4-chloro-2,6-dimethyl-3-nitropyridine 
• 110629-58-8 4-<(2-chloroethyl)amino>-2,6-dimethyl-3-nitropyridine 
• 125742-50-9 1-[4-chlorophenyl(pyridin-4-yl)methyl]piperazine 

Relevant articles and documents

Synthesis of basic substituted pyridines: a new class of antiasthmatic- antiallergic agents

A series of pyridines were synthesized and evaluated as bronchospasmolytic / anti-allergic agents.Several of these compounds were found to: 1) inhibit the release of histamine; 2) antagonize histamine, bradykinin, LTD4 and PAF; 3) suppress the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction.The most interesting substance of this series 2,6-dimethyl-3-nitro-4pyridine 1, (HWA 214), was selected for further pharmacological evaluation.The novel, orally active agent 1 does not have such drawbacks as causing drowsiness or being effective only as a prophylactic drug, and could provide advantages over other non-sedative compounds, such as terfenadine and astemizole, in that it is water soluble and thus can be administered through inhalation or through intravenous application.Keywords: pyridines / H1-antagonistic activity / antiallergic property / antiasthmatic property