110629-94-2Relevant academic research and scientific papers
α-Hydroxy thioethers
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, (2008/06/13)
Novel asymmetric thioethers of the formula STR1 in which the general symbols have the following meanings: a is an integer of from 1 to 7, Ro represents hydrogen or C1-7 -alkanoyl, R1 represents C1-3 -alkyl which may be substituted at the terminal carbon atom by a free or acylated hydroxy group, by a halogen atom having an atomic number of at most 17, or by methoxy, or represents C1-3 -perfluoroalkyl, R2 represents an optionally unsaturated aliphatic radical having from 5 to 15 carbon atoms, A represents ethylene or alternatively, if R1 represents a halogenated radical and/or B represents phenylene or ethylene, a single bond or vinylene, B represents a single bond, ethynylene or phenylene, R3 represents hydroxy, C1-7 -alkoxy or an optionally substituted amino group, and --X-- represents a single bond, a methylene group of an optionally N-acylated primary aminomethylene group, and their salts are active as leucotriene antagonists since they eliminate the contractions of smooth muscles brought about by leucotrienes, and are therefore suitable for the treatment of allergic, especially asthmatic, conditions.
