110661-59-1

Basic information

• Product Name: BENZENEMETHANESULFONYL CHLORIDE, 4-METHOXY-
• Synonyms: BENZENEMETHANESULFONYL CHLORIDE, 4-METHOXY-;(p-Methoxyphenyl)Methanesulfonyl chloride
• CAS NO: 110661-59-1
• Molecular Formula: C₈H₉ClO₃S
• Molecular Weight: 220.67
• Mol File: 110661-59-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 332.7±25.0 °C(Predicted)
• Appearance: /
• Density: 1.360±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: BENZENEMETHANESULFONYL CHLORIDE, 4-METHOXY-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEMETHANESULFONYL CHLORIDE, 4-METHOXY-(110661-59-1)
• EPA Substance Registry System: BENZENEMETHANESULFONYL CHLORIDE, 4-METHOXY-(110661-59-1)

Safety Data

• Hazardous Substances Data: 110661-59-1(Hazardous Substances Data)

Usage

Uses

(4-Methoxyphenyl)methanesulfonyl chloride (cas# 110661-59-1) is used as a reagent in the preparation of (aroyl)piperazine derivatives and detection of their activity for treatment of cerebral anoxia and cerebral ischemia.

Upstream product

• 25985-08-4 2-(4-methoxybenzyl)isothiourea hydrochloride 

Downstream Products

• 161315-27-1 N-(p-Methoxyphenylsulfonyl)glycine ethyl ester 
• 477908-17-1 methyl 2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanoate 
• 161314-70-1 N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide 
• 1027951-62-7 ethyl 2-(4-methyoxy-N-(pyridine-3-ylmethyl)phenylsulfonamido)acetate 
• 161314-48-3 N-hydroxy-2-(4-methoxy-N-(pyridine-3-ylmethyl)phenylsulfonamido)acetamide 
• 161315-46-4 methyl 2(R)-[(4-methoxyphenyl)sulfonyl amino]-3-methylbutanoate 

Relevant articles and documents

Nucleophilic Substitution Reaction of Phenylmethanesulfonyl Halides with Anilines

Kinetic studies on the nucleophilic substitution reaction of Y-substituted phenylmethanesulfonyl halides with X-substituted anilines in methanol-acetonitrile have been carried out in order to elucidate the reaction mechanism.The phenylmethanesulfonyl fluorides (PSF) had markedly lower rates and smaller magnitudes of ρX and ρY values compared with those for the chlorides (PSC).On the contrary, however, the magnitude of the cross-interaction constant ρXY was greater for PSF than for PSC, so that the degree of bond making in the transition state is actually greater in the reaction of PSF as compared with that for PSC.We have thus demonstrated that extensive charge transfer from a nucleophile to a substrate does not necessarily mean a tight bond in the transition state.Moreover the nonzero ρXY values obtained for both PSC and PSF are taken as evidence in support of a common, associative SN2 mechanism for the two halides.