1106736-38-2Relevant academic research and scientific papers
A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells
Wang, Menghua,Xia, Yi,Fan, Yuting,Rocchi, Palma,Qu, Fanqi,Iovanna, Juan L.,Peng, Ling
supporting information; experimental part, p. 5979 - 5983 (2010/11/02)
Novel arylethynyltriazole acyclonucleosides were synthesized and assessed for their anticancer activity on drug-resistant pancreatic cancer MiaPaCa-2 cells. One lead compound was found to have much more potent apoptosis-related antiproliferative effects than gemcitabine, the current first-line treatment for pancreatic cancer. Further investigations showed that this active compound did not inhibit DNA synthesis, which means that it does not resemble gemcitabine and may involve a different mechanism of action.
NOVEL VIRAL REPLICATION INHIBITORS
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Page/Page column 31, (2009/03/07)
The present invention relates to novel compounds and to their use as a medicament, more in particular for the treatment or prevention of viral infections in mammals. The invention also relates to processes for the preparation of compounds according to the
