110683-03-9

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 53839-60-4 retinoyl chloride 
• 302-79-4 all-trans-retinoic-acid 

Downstream Products

• 97885-88-6 N-(all-trans-retinoyl)-L-phenylalanine 
• 110769-98-7 2-[3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoylamino]-3-phenyl-propionic acid 

Relevant academic research and scientific papers

A simple, general and efficient method for O and N-retinoylation. Application to the synthesis of 2-retinoyl-lecithin

The synthesis of the new 1-stearoyl-2-retinoyl-glycero-3- phosphorylcholine by coupling of retinoic acid and lysolecithin with DCC- DMAP (1.2 eq.) is reported. This method is applied to O and N-retinoylation of uncharged organic substrates such as aliphatic alcohols, free hydroxyl anomeric sugars, aromatic amines and C-protected α-aminoacids.

N-(retinoyl)amino acids, synthesis and chemopreventive activity in vitro

N-(all-trans-Retinoyl)amino acids were synthesized via all-trans-retinoyl chloride and an ester of the amino acid. The retinoyl derivatives of leucine, phenylalanine, alanine, tyrosine, and glutamic acid were prepared. The 13-cis-retinoyl derivatives of l