110683-22-2

Basic information

• Product Name: 8-Amino-4-oxo-2-(tetrazol-5-yl)-4H-1-benzopyran
• Synonyms: 8-AMINO-4-OXO-2-(1H-TETRAZOLE-5-YL)-4H-1-BENZOPYRAN HYDROCHLORIDE;8-AMino-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one hydrochloride;8-Amino-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one (Pranlukast);8-Amino-2-(1H-tetrazol-5-yl);8-AMINO-2-(1H-TETRAZOL-5-YL)-4H-1-BENZOPYRAN-4-ONE;8-amino-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one (intermediate of pranlukast);8-Amino-4-oxo-2-(tetrazol-5-yl)-4H-1-benzopyran;8-Amino-2-tetrazol-5-yl-4-oxo-4H-1-benzopyran
• CAS NO: 110683-22-2
• Molecular Formula: C₁₀H₇N₅O₂
• Molecular Weight: 229.19488
• EINECS: 1312995-182-4
• Product Categories: Amines;(intermediate of pranlukast);Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 110683-22-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: >280°C (dec.)
• Boiling Point: 504.409 °C at 760 mmHg
• Flash Point: 258.858 °C
• Appearance: Yellow solid
• Density: 1.642
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 5.00±0.10(Predicted)
• CAS DataBase Reference: 8-Amino-4-oxo-2-(tetrazol-5-yl)-4H-1-benzopyran(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Amino-4-oxo-2-(tetrazol-5-yl)-4H-1-benzopyran(110683-22-2)
• EPA Substance Registry System: 8-Amino-4-oxo-2-(tetrazol-5-yl)-4H-1-benzopyran(110683-22-2)

Safety Data

• Hazardous Substances Data: 110683-22-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Pranlukast intermediate.

Upstream product

• 614-80-2 2-(acetylamino)phenol 
• 141283-42-3 8-nitro-4-oxo-2-(5-1H-tetrazolyl)-4H-1-benzopyran 

Downstream Products

• 103177-41-9 8-(p-octylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 
• 103177-37-3 pranlukast 
• 103177-14-6 8-(p-butoxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 
• 110683-56-2 (E)-3-(4-Heptyloxy-phenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-acrylamide 
• 110683-55-1 (E)-3-(4-Hexyloxy-phenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-acrylamide 
• 103177-35-1 8-[p-(3-phenylpropoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 
• 103177-42-0 8-(p-nonylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 
• 110683-54-0 (E)-3-(4-Heptyl-phenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-acrylamide 
• 110683-52-8 (E)-3-(4-Butyl-phenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-acrylamide 
• 103177-18-0 8-(p-nonyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 
• 103177-19-1 8-(p-octyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 
• 103177-16-8 8-(p-hexyloxybenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 
• 110683-53-9 (E)-3-(4-Hexyl-phenyl)-N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-acrylamide 
• 103177-40-8 8-(p-heptylbenzoyl)amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 

Relevant articles and documents

Preparation method of pranlukast intermediate

The invention provides a preparation method of a pranlukast intermediate. A compound C serving as a raw material reacts obtain the pranlukast intermediate. The preparation method has the advantages that the reaction condition is relatively mild, the operation is convenient, the purity and the yield of the obtained pranlukast intermediate are high, and the method is suitable for industrial production, so that a more valuable synthesis route is provided for preparation of pranlukast, good social benefits and economic benefits can be generated, and the economic potential is great.

Process for preparing benzopyran compounds

The present invention relates to a process for preparing compounds of structure (I), and the intermediate compound of formula (II).