110683-72-2

Basic information

• Synonyms: 2-Benzofurancarboxylic acid, 7-nitro-, ethyl ester;Ethyl 7-nitrobenzofuran-2-carboxylate
• CAS NO: 110683-72-2
• Molecular Formula: C₁₁H₉NO₅
• Molecular Weight: 235.19286
• Mol File: 110683-72-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90-91 °C
• Boiling Point: 359.7±22.0 °C(Predicted)
• Appearance: /
• Density: 1.362±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N/A(CAS DataBase Reference)
• NIST Chemistry Reference: N/A(110683-72-2)
• EPA Substance Registry System: N/A(110683-72-2)

Safety Data

• Hazardous Substances Data: 110683-72-2(Hazardous Substances Data)

Upstream product

• 5274-70-4 3-nitrosalicylic aldehyde 
• 110683-71-1 ethyl (2-formyl-6-nitrophenoxy)acetate 
• 685-87-0 Diethyl 2-bromomalonate 
• 3199-61-9 ethyl coumarilate 

Downstream Products

• 115464-80-7 1-(7-benzofuranyl)-4-<3-(4-fluorobenzoyl)propyl>piperazine hydrochloride 
• 115464-77-2 2-<<4-(7-benzofuranyl)-1-piperazinyl>methyl>-5-(4-fluorophenyl)pyrrole 
• 18761-32-5 nitro-7 benzofuranne 

Relevant articles and documents

ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

Compounds are provided which are useful for the treatment of serotonin-affected neurological disorders which comprise (I) wherein: Ra, R1, R2 and R3 are each, independently, hydrogen, or a substituent selected from halogen, CF3, alkyl, alkoxy, MeSO2, amino or aminocarbonyl (each optionally substituted by one or two groups selected from alkyl and benzyl) carboxy, or alkoxycarbonyl; or two adjacent of Ra and R1-4 together can form a 5-7 membered carbocyclic or heterocyclic ring which is optionally substituted by a substituent defined above; R4 is hydrogen, halogen, or alkyl; R5 is hydrogen, alkyl, arylalkyl, or aryl; R6 is hydrogen, halogen, CF3, CN, carbamide, alkoxy or benzyloxy; X1, X2 and X3 are each carbon or one of X1, X2 or X3 may be nitrogen; Y is CH or nitrogen; and Z is carbon or nitrogen; or pharmaceutically acceptable salts thereof.

2-Phenylpyrroles as Conformationally Restricted Benzamide Analogues. A New Class of Potential Antipsychotics. 2

A series of 2-phenylpyrrole Mannich bases was synthesized and screened in pharmacological models for antipsychotic activity and extrapyramidal effects.Structure modifications of 5-(4-fluorophenyl)-2-methyl>pyrrole (1), the prototype of a new class of sodium-independent atypical dopamine D-2 antagonists, resulted in 2-methyl>-5-(4-fluorophenyl)pyrrole (15), which was an even more potent and selective D-2 antagonist than the parent compound.The excellent oral activity in the apomorphine-induced climbing behavior and the conditioned avoidance response tests and the absence of catalepsy make this compound particularly promising as a potential antipsychotic with a low propensity to induce acute extrapyramidal side effects.