1106977-85-8

Basic information

• Product Name: (3-{3-[(2,2-Diphenyl-ethyl)-(2-fluoro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetic acid methyl ester
• Synonyms: (3-{3-[(2,2-Diphenyl-ethyl)-(2-fluoro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetic acid methyl ester
• CAS NO: 1106977-85-8
• Molecular Weight: 579.635
• Mol File: 1106977-85-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-{3-[(2,2-Diphenyl-ethyl)-(2-fluoro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3-{3-[(2,2-Diphenyl-ethyl)-(2-fluoro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetic acid methyl ester(1106977-85-8)
• EPA Substance Registry System: (3-{3-[(2,2-Diphenyl-ethyl)-(2-fluoro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetic acid methyl ester(1106977-85-8)

Safety Data

• Hazardous Substances Data: 1106977-85-8(Hazardous Substances Data)

Upstream product

• 184970-25-0 1-(bromomethyl)-2-fluoro-3-(trifluoromethyl)benzene 
• 1106977-81-4 {3-[3-(2,2-diphenyl-ethylamino)-propoxy]-phenyl}-acetic acid methyl ester 

Downstream Products

• 437991-39-4 DY₁₃₆ 

Relevant articles and documents

SYNTHETIC LIGANDS SELECTIVE FOR LXRbeta OVER LXRalpha, IDENTIFICATION AND METHODS OF USE THEREOF

LXR nuclear receptor agonists have been previously shown to increase cholesterol efflux, raise plasma HDL cholesterol, stimulate cholesterol excretion, and reduce atherosclerotic lesions. However, these agonists have also been associated with the unwanted side effect of hypertriglyeridemia. This hypertriglyeridemia appears to be mediated by the LXRalpha subtype rather than LXRbeta, which suggests that LXRbeta-selective agonists are attractive candidates for modulation of human lipid metabolism. The present application provides novel LXRbeta-selective ligands that preferably modulate LXRbeta over LXRalpha. These ligands may be used to treat a variety of diseases associated with LXR, such as for example lipid metabolism disorders, atherosclerosis, Alzheimer disease, and inflammation.